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TranscriptomicsCPD-seq mapping of UV damage formation and repair in yeast
UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. We have used a novel high-throughput sequencing method to precisely map UV-induced cyclobutane pyrimidine dimers (CPD...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-19 | E-GEOD-79977 | biostudies-arrayexpress
MetabolomicsChemodiverse cell systems responses to UV in an algal sister of land plants

Plant terrestrialization necessitated overcoming a barrage of stressors. Embryophytes (land plants) use an integrated response network to adjust their molecular physiology in response to terrestrial stressors—one of the important stressors is UV irradiance. The zygnematophytes are the closest str...

2026-07-01 | MTBLS8088 | MetaboLights
TranscriptomicsIdentification of intermediate-sized non-coding RNAs involved in the UV-induced DNA damage response in C. elegans
We utilized high-throughput RNA-seq to uncover the intermediate-sized noncoding RNAs invovled in UV-DNA Damage Responses in C. elegans. 450 novel transfrags were discovered, some of which show dramatic expression change between the UV irradiation and control. This study should lead to a better under...
ORGANISM(S): Caenorhabditis elegans 
2012-05-01 | E-GEOD-37063 | biostudies-arrayexpress
ProteomicsProteomic profiling of UV damage repair patches
DNA damage compromises not only genome stability but also the integrity of the chromatin template, which plays a central role in controlling cell identity. Our understanding of chromatin repair mechanisms is very incomplete. To bridge this knowledge gap, here we devised a novel proteomic strategy to...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD055129 | Pride
Uv damage repair Chromatin Ipond Nanolc-ms/ms 
TranscriptomicsRoles for the Transcription Elongation Factor NusA in Both DNA Repair and Damage Tolerance Pathways in Escherichia coli
Here we report our observations that have led us to propose that the transcription elongation factor NusA promotes a novel class of transcription-coupled repair (TCR) in addition to its previously proposed role in recruiting translesion synthesis (TLS) DNA polymerases to gaps encountered during tran...
ORGANISM(S): Escherichia coli 
2010-07-14 | E-GEOD-22829 | biostudies-arrayexpress
ProteomicsProteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms
Ultraviolet (UV)-induced DNA lesions threaten genomic stability and are associated with skin carcinogenesis. These lesions are primarily repaired by the nucleotide excision repair (NER) pathway. However, alternative repair mechanisms and regulators are emerging as critical contributors to managing U...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD061212 | Pride
Uv Uv Dek Numa1 Dna damage 
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis uvr8-1 and hy5-1 mutants exposed to UV-B and white light
This experiment tests the effect of physiological dose of UV-B radiation on wild-type and uvr8-1 (UV Resistance Locus 8) and hy5-1 transcription factor mutants of Arabidopsis.
ORGANISM(S): Arabidopsis thaliana 
2007-06-27 | E-GEOD-3533 | biostudies-arrayexpress
GenomicsExcision repair hotspots of UV-induced DNA damage in the human genome
Excision repair hotspots of UV-induced DNA damage in the human genome
PRJNA623860 | ENA
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