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ProteomicsMultiomicsTracks96: A high throughput PIXUL-Matrix-based toolbox to profile frozen and FFPE tissues multiomes
Background: The multiome is an integrated assembly of distinct classes of molecules and molecular properties, or “omes,” measured in the same biospecimen. Freezing and formalin-fixed paraffin-embedding (FFPE) are two common ways to store tissues, and these practices have generated vast biospecimen r...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-14 | PXD041462 | Pride
Matrix-chip Matrix-merip Matrix-rt Multiomicstracks96 Pixul Matrix-medip Segway Cryogrid Lc-ms/ms 
ProteomicsProteomics Analysis of Skeletal Muscle in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy
Prostate cancer (PCa) is the second most common cancer in men and negatively impact muscle mass, physical function, and patient-reported outcomes. Androgen deprivation therapy (ADT) is a widely used treatment for advanced disease, but it exacerbates these adverse effects. To investigate the molecula...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD061070 | Pride
Skeletal muscle Androgen deprivation therapy Data-independent acquisition Prostate cancer 
ProteomicsA lysosome-targeted DNA nanodevice selectively targets macrophages to attenuate tumors
Activating CD8+ T cells by antigen cross-presentation is remarkably effective at eliminating tumors. Although this function is traditionally attributed to dendritic cells, tumor-associated macrophages (TAMs) can also cross-present antigens. TAMs are the most abundant tumor-infiltrating leukocyte. Ye...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-14 | PXD028037 | Pride
Antigen cross-presentation Lc-msms Cancer Cysteine proteases Macrophages Lysosomes 
ProteomicsApolipoprotein A-II Increases Cholesterol Efflux Capacity of Mature High-Density Lipoproteins Via the Apolipoprotein A-I C-terminus
Samples were processed using Global and Limited Proteolysis (LiP). Peptides and proteins were identified using MaxQuant (v1.6.17.0), then summarized using R package RomicsProcessor.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-29 | MSV000095479 | MassIVE
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