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ProteomicsProteomic analysis of serum EVs derived from PSC, CCA and PSC-CCA patients
Cholangiocarcinomas (CCAs) are heterogeneous biliary cancers with dismal prognosis. Their etiologies remain mostly unclear, although primary sclerosing cholangitis (PSC) is a well-known risk factor. There is an urgent need of accurate non-invasive biomarkers for early CCA diagnosis and to predict pa...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD026197 | Pride
Psc Liver Evs Cca 
ProteomicsLiquid biopsy protein biomarkers of cholangiocarcinoma risk, early diagnosis and survival mirroring tumor cells - timsTOF (2/2)
Background & Aims: Cholangiocarcinomas (CCAs), heterogeneous biliary tumors with dismal prognosis, lack accurate early-diagnostic methods, especially important for individuals at high-risk (i.e., primary sclerosing cholangitis (PSC)). Here, we searched for protein biomarkers in serum extracellular v...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037007 | Pride
Cca Serum Extracellular vesicles Timstof 
ProteomicsLiquid biopsy protein biomarkers of cholangiocarcinoma risk, early diagnosis and survival mirroring tumor cells - timsTOF (1/2)
Background & Aims: Cholangiocarcinomas (CCAs), heterogeneous biliary tumors with dismal prognosis, lack accurate early-diagnostic methods, especially important for individuals at high-risk (i.e., primary sclerosing cholangitis (PSC)). Here, we searched for protein biomarkers in serum extracellular v...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036943 | Pride
Cholangiocarcinoma  extracellular vesicles  primary sclerosing cholangitis  biomarkers  liquid biopsy  single-cell rna-sequencing  mass spectrometry 
ProteomicsSearch for synaptic biomarkers of Alzheimer’s disease
As synapse degeneration is an early event in Alzheimer’s disease (AD) pathophysiology, a biofluid marker of synapse loss in living patients could be a surrogate marker of disease prognosis and therefore would be an excellent addition to the AD biomarker arsenal. With direct access to the brain inter...
ORGANISM(S): Homo Sapiens 
2019-01-10 | PXD012138 | panorama
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