Valve interstitial cells

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Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA (1)
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The Center for Excellence in Vascular Biology, Cardiovascular Division The Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (1)

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Single cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity

This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...

ORGANISM(S): Mus musculus

2018-07-13 | E-HCAD-18 | biostudies-arrayexpress

Proteomics comparison of human valve interstitial cells from healthy patients and donors with CAVD

Calcific aortic valve disease (CAVD) is an slowly progressive calcification of heart valve which leads to aortic stenosis. The only existing treatment of CAVD is surgical replacment of calcified valve - development of anti-CAVD treatment is urgent task. For better understanding of molecular mechanis...

ORGANISM(S): Homo sapiens (Human)

2022-10-21 | PXD032212 | Pride

Gene expression from healthy male and female porcine aortic valve leaflets

Calcific aortic valvular disease (CAVD) is characterized by sclerosis of the aortic valve leaflets and recent clinical studies have linked several other risk factors to this disease, including male sex. In this study we examined potential sex-related differences in gene expression profiles between ...

ORGANISM(S): Sus scrofa

2013-01-02 | E-GEOD-33654 | biostudies-arrayexpress

Expression analysis of human aortic valve interstitial cells (hAVICs), mitral valve interstitial cells(hMVICs) and dermal firbroblasts (hDFs)

Investigation of whole genome gene expression level changes in hAVICs and hMVICs, compared to human dermal fibroblasts. A three chip assay using total RNA obtained from primary cultured normal valve interstital cells and human dermal fibroblasts was performed. Each chip measures the expression level...

ORGANISM(S): Homo sapiens

2013-06-30 | E-GEOD-40801 | biostudies-arrayexpress

Comparative analysis of DDA- and DIA-PASEF methods for proteomics analysis of human valve interstitial cells and osteoblasts during osteogenic differentiation

Shotgun proteomics is one of the key "omics" methods, the methodology of which is rapidly developing. Mass spectrometers of the TimsToF series (Bruker) with ion mobility are one of the young technological platforms for shotgun proteomics in which both data dependent (DDA) and data independent acquis...

ORGANISM(S): Homo sapiens (Human)

2024-11-12 | PXD036566 | Pride

Data independent acquisition Pasef Shotgun proteomics Homo sapiens Timstof pro Calcific aortic valve disease

Crenigacestat inhibits osteogenic differentiation of human valve interstitial cells and seems promising for treatment of cardiovascular calcification

Vascular calcification is common pathology various forms of which presented in the half of humans. Calcific aortic valve disease (CAVD) is one of the most dangerous forms of vascular calcification. Despite high mortality there is no target therapy against CAVD. Thus, we tested crenigacestat (LY30394...

ORGANISM(S): Homo sapiens (Human)

2022-10-04 | PXD029632 | Pride

Valve intersticial cells Timstof pro Vascular calcification Ly3039478 Notch inhibitors Crenigacestat Calcific aortic valve disease Shotgun proteomics

Proteomics analysis of physiological effect of ZBTB16 (PLZF) on osteogenic differentiation of human valve interstitial cells (VICs) by DDA PASEF on TimsToF Pro

During fundamental proteotranscriptomic analysis of human valve interstitial cells (VICs) osteogenic differentiation, we revealed ZBTB16 (PLZF) as one of the most upregulated proteins. Thus, to investigate its physiological role in VICs osteogenic differentiation we performed its overexpression by l...

ORGANISM(S): Homo sapiens (Human)

2022-10-21 | PXD031572 | Pride

Zbtb16 plzf osteogenic differentiation valve interstitial cells pasef timstof pro

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling ...

ORGANISM(S): Rattus norvegicus

2011-08-25 | E-GEOD-31668 | biostudies-arrayexpress

Stretch responsive miRNAs in human aortic valve interstitial cells

miRNA-Sequencing was performed on human aortic valve interestitial cells (AVICs) exposed to 14% stretch at 1 hz or static conditions for 24h. Six static control and six samples exposed to cyclic stretch 14% for 24h

ORGANISM(S): Homo sapiens

2015-01-09 | E-GEOD-49558 | biostudies-arrayexpress

Exploring Genes Regulated by circHIPK3 in Aortic Valve Interstitial Cells

PRJNA1070301 | ENA

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