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TranscriptomicsTranscription profiling of endothelial cells from opposite sides of aortic valves from healthy adult male pigs
Differential transcriptional profiles from endothelial cells isolated from opposite sides of aortic valves from healthy adult male pigs (N=8, from slaughterhouse). Samples were hybridized to a human array and paired by animal.
ORGANISM(S): Sus scrofa 
2007-07-14 | E-CBIL-32 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expression in endothelial-derived cells
Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart disease. At localized swellings of extracellular matrix known as the endocardial cushions, the endothelial lining of the heart undergoes an epithelial to mesenchy...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5298 | biostudies-arrayexpress
TranscriptomicsGene expression profile of calcified and normal tricuspid aortic valves by RNA sequencing.
Purpose: Calcific aortic valve stenosis (AS) is a fatal disease with currently no medical therapy. Some genes were associated with AS, but the genetic architecture of the disease has yet to be discovered. The objective of this study was to combine genome-wide association studies (GWAS) and gene expr...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-55492 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
TranscriptomicsGene expression profile of normal and calcified stenotic human aortic valves
We explored gene expression profile of human aortic valves in patients with or without aortic stenosis. The dataset that we generated constitutes a large-scale quantitative measurements of gene expression in normal and stenotic human valves. The goal was to compare gene expression levels between the...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-12644 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity
This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...
ORGANISM(S): Mus musculus 
2018-07-13 | E-HCAD-18 | biostudies-arrayexpress
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
TranscriptomicsTranscription profiling of cardiac valves from patients with bacterial infectious endocarditis
Transcriptional profiles of cardiac valves from patients with bacterial infectious endocarditis (3 infected with Streptococcus sp. and 2 infected with Staphylococcus aureus) were compared with uninfected cardiac valves (7 patients) from patients with hemodynamic disturbing events
ORGANISM(S): Homo sapiens 
2009-10-23 | E-MEXP-1334 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human heart valves
Semilunar valve leaflets have a well-described trilaminar histoarchitecture with a sophisticated elastic fiber network. It was previously proposed that elastin-containing fibers play a subordinate role in early human cardiac valve development; however, this assumption was based on data obtained from...
ORGANISM(S): Homo sapiens 
2013-04-06 | E-GEOD-45821 | biostudies-arrayexpress
TranscriptomicsExpression data from static and cyclic stretched porcine aortic heart valves
We explored the hypothesis that Serotonin (5HT) receptor signaling, that can be enhanced with 5HT transporter blockade with Fluoxetine (Fluox), in the aortic valve may vary based upon the biomechanical activity of the aortic valve leaflet. We used Affymetrix microarrays to study gene expression prof...
ORGANISM(S): Sus scrofa 
2010-05-27 | E-GEOD-21663 | biostudies-arrayexpress
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