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ProteomicsControl of synaptic vesicle release probability via VAMP4 targeting to endolysosomes
The probability of synaptic vesicle (SV) fusion in response to an action potential, termed vesicular release probability (Pr), is a stochastic but tightly regulated process. SNARE proteins are the molecular executors of SV fusion and therefore, key modulators of Pr. The non-canonical SNARE VAMP4 is ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD021437 | Pride
Endosome Neurotransmitter Synaptic plasticity Release probability Vamp4 Lysosome Synaptic vesicle Endocytosis 
UnknownVAMP4 regulates insulin levels by targeting secretory granules to lysosomes.
Not available
S-EPMC9441717 | biostudies-literature
UnknownVAMP4 Is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis.
Not available
S-EPMC4678114 | biostudies-literature
UnknownAnalysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.
Not available
S-EPMC7762821 | biostudies-literature
UnknownControl of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.
Not available
S-EPMC8087399 | biostudies-literature
UnknownVAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells.
Not available
S-EPMC3438144 | biostudies-literature
UnknownVAMP4 in hypoxic adipose stem cell exosomes alleviates ischemia-reperfusion injury.
Not available
S-EPMC12748495 | biostudies-literature
TranscriptomicsUnexpected roles of ATP11B in platinum resistance
Platinum compounds display clinical activity against a wide variety of solid tumors. However, resistance to these agents is a major limitation in cancer therapy. Reduced platinum uptake and increased platinum export are examples of resistance mechanisms that limit the extent of DNA damage. Here, we ...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-43694 | biostudies-arrayexpress
ProteomicsLC-MS/MS proteomics analysis of neuronal cells and secretomes with timsTOF Pro
The neuropeptide VGF was recently proposed as a neurodegeneration biomarker. The Parkinson's disease-related protein leucine-rich repeat kinase 2 (LRRK2) regulates endolysosomal dynamics, a process that involves SNARE-mediated membrane fusion and could regulate secretion. Here we investigate potenti...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-31 | PXD028321 | Pride
Vamps Parkinson’s disease Secretome Neuronal cells Timstof pro Lc-ms/ms 
UnknownDirect targeting of membrane fusion by SNARE mimicry: Convergent evolution of Legionella effectors.
Not available
S-EPMC4978295 | biostudies-literature
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