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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsA comprehensive map of L1HS-Ta retrotransposons in a panel of human cells obtained by ATLAS-seq.
We used ATLAS-seq to comprehensively map the genomic location of LINE-1 elements belonging to the youngest and potentially polymorphic subfamily (L1HS-Ta). This was performed in a panel of 12 human primary or transformed cell lines (BJ, IMR90, MRC5, H1, K562, HCT116, HeLa S3, HepG2, MCF7, HEK-293, H...
ORGANISM(S): Homo sapiens 
2016-05-24 | E-MTAB-4676 | biostudies-arrayexpress
TranscriptomicsLongitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41867 | biostudies-arrayexpress
TranscriptomicsMicroRNAs regulate DC maturation via M-CSFR
We identify a panel of microRNAs that are differentially expressed during both spontaneous and LPS-induced DC maturation and show the M-CSF receptor (M-CSFR) as a key target for microRNA-mediated regulation. MicroRNA-22, -34a and -155 are up-regulated in mature GM-CSF-generated DC and mediate M-CSFR...
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3311 | biostudies-arrayexpress
UnknownSuperconductivity in Metal-Rich Chalcogenide Ta2Se.
Not available
S-EPMC7304865 | biostudies-literature
UnknownHeavy fermions vs doped Mott physics in heterogeneous Ta-dichalcogenide bilayers.
Not available
S-EPMC10866876 | biostudies-literature
TranscriptomicsTranscription profiling of S. cerevisiae to fermentative conditions
The capacity of respiring cultures of Saccharomyces cerevisiae to instantaneously switch to fast alcoholic fermentation upon a transfer to anaerobic sugar-excess conditions is a key characteristic of Saccharomyces cerevisiae in many of its industrial applications. This transition was studied by expo...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-18 | E-GEOD-8187 | biostudies-arrayexpress
TranscriptomicsIdentification of direct T-box target genes in the developing zebrafish mesoderm
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the gen...
ORGANISM(S): Danio rerio 
2010-05-19 | E-GEOD-12857 | biostudies-arrayexpress
ProteomicsIdentification of the MuRF1 skeletal muscle ubiquitylome through quantitative proteomics
MuRF1 is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans, and is a recognized marker of muscle atrophy. In this study, we used in vivo electroporation ...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD023872 | Pride
Ubiquitin proteomics Muscle atrophy Murf1 Protein degradation Electroporation 
MetabolomicsAMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP-activated kinase (AMPK), a central energy sensor promoting c...
2024-08-16 | MTBLS10647 | MetaboLights
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