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ProteomicsPhosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms
The mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases, and cells closely monitor membrane potential as an indic...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-15 | PXD037405 | Pride
Mitochondria Phosphate 
ProteomicsIdentification of Small molecule Insulin Sensitizers for the Treatment of Insulin Resistance.
Type 2 diabetes (T2D) is major cause of mortality and morbidity. The key manifestations of this disease are insulin resistance (IR), hyperglycemia and hyperinsulinemia. Secretion of insulin from the endocrine pancreas is triggered by elevated circulating glucose and acts on skeletal muscle and adipo...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD034052 | Pride
Small molecule drug Diabetes 
ProteomicsMustn1 is a smooth muscle cell-secreted micropeptide that modulates skeletal muscle extracellular matrix composition
We show that Mustn1 (Musculoskeletal embryonic nuclear protein 1, also known as Mustang) is highly expressed in skeletal muscle during the early stages of hindlimb reloading. Mustn1 expression is transiently elevated in mouse and human skeletal muscle in response to intense exercise, resistance exer...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047169 | Pride
Skeletal muscle Extracellular matrix 
ProteomicsAmelioration of Pathologic -Synuclein-Induced Parkinson’s Disease by Irisin
Physical activity is thought to provide clinical benefit in Parkinson’s diseas (PD). Irisin is a blood-brain barrier permeable exercise-induced polypeptide secreted by muscle that mediates, in part, the beneficial effects of exercise. Here we show that irisin prevents pathologic -synuclein (-syn) in...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD032670 | Pride
Irisin Alpha-synuclein Neurodegeneration Parkinson’s disease 
ProteomicsIsolation of interstitial fluids reveals novel secreted bioactive proteins from muscle and fat tissues
Proteins are secreted from various cells to send information to neighboring cells or distant tissues. Because of the highly integrated nature of energy balance systems, there has been a great deal of interest in myokines and adipokines, proteins secreted from muscle and fat tissues, respectively. Th...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-10 | PXD037731 | Pride
Brown fat Interstial fluid Muscle 
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