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ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
GenomicsNon-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis
Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here we find that the non-canonical PRC1.1 complex, as identified by mass spectrometry-based proteomics, is critically important for human leukemic stem cells. D...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-54580 | biostudies-arrayexpress
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