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This project is aimed at characterizing the interactions of SARS-CoV-2 Spike protein and its variants with multiple full-length antibodies and monitoring the accompanying conformational dynamics. Different categories of antibodies are tested that recognize different domains of the Spike protein. The...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD043818 | Pride
Quantification of Spike cleavage across different Sars-Cov2 variants by partial reaction monitoring mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD027641 | Pride
Identification of host dependency factors shared by multiple SARS-CoV-2 variants of concern
Effects of Ancestral SARS-CoV-2 versus Variants of Concern Delta and Omicron on Megakaryocyte Activation and Transcriptome
Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-Cov-2 variants of concern
Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037265 | Pride
CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern
Upper respiratory infection drives clinical signs and inflammatory responses in heterologous challenge of SARS-CoV-2 variants of concern
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperreactive platelet phenotype, which is thought to contribute to the high incidence of thrombosis in COVID-19 patients. Mutations of SARS-CoV-2 resulted in several virus variants with differences in transm...
ORGANISM(S): Homo sapiens 
2025-08-20 | GSE277576 | GEO
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