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ProteomicsPiezo1 integration of vascular architecture with physiological force LC-MSMS
The mechanisms by which physical forces regulate cells to determine complexities of vascular structure and function are enigmatic. Here we show the role the ion channel subunit Piezo1 (FAM38A). Disruption of mouse Piezo1 gene disturbed vascular development and was embryonic lethal within days of the...
ORGANISM(S): Homo sapiens (Human) 
2014-08-08 | PXD001099 | Pride
Shear stress Human Mouse Piezo1 Label-free Phosphoproteomics Huvec Vascular architecture 
ProteomicsIntermittent Fasting Reprograms the Brain Proteome to Prevent Synaptic Degeneration and Cognitive Impairment in Vascular Dementia
Vascular dementia (VaD), driven by chronic cerebral hypoperfusion (CCH), leads to synaptic degeneration and cognitive decline, yet mechanisms linking vascular dysfunction to synaptic loss remain unclear. Intermittent fasting (IF) has emerged as a potential intervention, but its effects on synaptic i...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD064537 | Pride
Vascular dementia Intermittent fasting Synapse Mouse hippocampus 
UnknownNogo-A regulates vascular network architecture in the postnatal brain.
Not available
S-EPMC5381465 | biostudies-literature
ProteomicsA vascular phosphoproteome atlas unveils a functional Tie‑Wnt signalling axis in the liver
Single cell transcriptomic analyses (scRNAseq) of hepatocytes and liver endothelial cells (L-EC) have revolutionized the understanding of the spatial architecture of liver structure and function. The spatial alignment of L-EC and hepatocytes is pivotal for liver function in health and disease given ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-21 | PXD020805 | Pride
Wnt Vasculature Liver Phospho-proteome Endothelial Zonation Tie 
GenomicsSpatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [Hi-C]
Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [Hi-C]
PRJNA1372082 | ENA
GenomicsSpatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [CUT&Tag]
Spatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome [CUT&Tag]
PRJNA1372081 | ENA
UnknownWhole-Brain Vascular Architecture Mapping Identifies Region-Specific Microvascular Profiles In Vivo.
Not available
S-EPMC11392379 | biostudies-literature
UnknownActive Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.
Not available
S-EPMC3056599 | biostudies-literature
UnknownThe inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity.
Not available
S-EPMC12495022 | biostudies-literature
UnknownA new interpretation on vascular architecture of the cauline system in Commelinaceae (Commelinales).
Not available
S-EPMC6586312 | biostudies-literature
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