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ProteomicsImpact of immunoproteasome impairment on microglia cell function
The ubiquitin-proteasome system maintains the functional proteome of the cells by the clearance of damaged, misfolded, old and/or unneeded proteins. This is particularly important in the brain where protein accumulation has a hallmark of many neurodegenerative diseases that drives neuroinflammation....
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD034900 | Pride
Neuroinflammation Proteomics Immunoproteasome Cns Ups Microglia Proteostasis 
ProteomicsRole of the DDI2 protease in activation of TCF11/NRF1 and cellular control
DDI2 has been shown to cleave and activate the ER-bound transcription factor TCF11/NRF1 (NFE2L1), a master regulator of proteostasis maintenance in mammalian cells, to ensure expression of rescue factors including proteasome subunits upon proteotoxic stress. Recent studies have identified DDI1-like ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD034079 | Pride
Lc-ms/ms Ea.hy926 cells Ddi2 
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