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TranscriptomicsL10_transcriptome
Transcriptional profile of inbreeding depression expressing as extreme cold-sensitivity. The experiment is a crossdesign of a conditional lethal line and an inbred control line, at permissive and a restrictive conditions (the latter involving a cold shock)
ORGANISM(S): Drosophila melanogaster 
2013-11-26 | E-MTAB-2120 | biostudies-arrayexpress
TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
ProteomicsOn-chip AP-MS: Interaction proteomics on a microfluidics platform
Here we present a microfluidics-based affinity purification-mass spectrometry (AP-MS) pipeline to identify protein-protein interactions (PPI) using minute amounts of input material. The use of this automated platform allowed us to identify the human cohesin and CCC complex from only 4 micrograms of ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD011323 | Pride
Interaction proteomics Low input Ap-ms 
ProteomicsOn-chip AP-MS: Interaction proteomics on a microfluidics platform
Essentially all cellular processes are orchestrated by protein-protein interactions (PPIs). In recent years, affinity purification coupled to mass spectrometry (AP-MS) has been the preferred method to identify cellular PPIs. Here we present a microfluidics-based (AP-MS) workflow to identify PPIs usi...
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD012800 | Pride
Interaction proteomics Low input Ap-ms 
TranscriptomicsTranscription profiling of mouse small intestine reveals fasting induces a biphasic adaptive metabolic response
Background; The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results; In...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-8019 | biostudies-arrayexpress
ProteomicsTitration of Sall4 by the NuRD complex facilitates neural differentiation of ES cells
Sall4 is a transcription factor essential for early mammalian development. Though it is reported to play an important role in embryonic stem (ES) cell self-renewal, whether it is an essential pluripotency factor has been disputed. Though Sall4 is known to associate with the Nucleosome Remodeling and...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-02 | PXD003614 | Pride
Ap-ms of flag-tagged sall4 in mouse embryonic stem cells 
UnknownReplication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Not available
S-EPMC6584130 | biostudies-literature
Proteomics‘Off the shelf’ proximity biotinylation for interaction proteomics
Proximity biotinylation workflows typically require CRISPR-based genetic manipulation of target cells. To overcome this bottleneck, we fused the TurboID proximity biotinylation enzyme to Protein A. Upon target cell permeabilization, the ProtA-Turbo enzyme can be targeted to proteins of interest usin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-07-12 | PXD025012 | Pride
Flywch1 Proximity labelling Turboid Interactome Protein a 
UnknownExpectations and disappointments relative to COVID-19 passes: results from a voluntary mixed-methods study in French-speaking Belgium.
Not available
S-EPMC9884140 | biostudies-literature
UnknownQuantification of corruption in preventative cost-based S-LCA: a contribution to the Oiconomy project.
Not available
S-EPMC6383569 | biostudies-literature
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