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ProteomicsImprovements in glycoproteomics through architecture changes to the Orbitrap Tribrid MS platform
Hardware changes introduced on the Orbitrap Ascend MultiOmics Tribrid MS include dual ion routing multipoles (IRMs) that can enable parallelized accumulation, dissociation, and Orbitrap mass analysis of three separate ion populations. The balance between these instrument functions is especially impo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-14 | PXD058153 | Pride
N-glycopeptides Fragmentation Glycoproteomics Tandem mass spectrometry O-glycopeptides Electron transfer dissociation 
ProteomicsUnderstanding m/z range settings for MS/MS scans: a case study with intact glycopeptides
Several practical considerations dictate the scan range, or breadth of ion m/z values, that can be transmitted through ion guides in mass spectrometers (MS). Voltage settings must be balanced to minimize low m/z cutoffs while also generating effective pseudopotential wells for high m/z ions to maxim...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD062360 | Pride
Glycobiology Glycopeptides Mass spectrometry Mass range 
ProteomicsElucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that when activated by their ligands, can elicit a wide range of healthy and disease-related processes such as cell proliferation and the epithelial-to-mesenchymal transition (EMT). The detailed molecular pathway dynamics...
ORGANISM(S): Homo Sapiens 
PXD039005 | panorama
ProteomicsTemporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons
At neuronal synapses, activation of group I metabotropic glutamate receptors (mGluR1/5) triggers a form of long-term depression (mGluR-LTD) that relies on new protein synthesis and the internalization of AMPA-type glutamate receptors. Dysregulation of these processes has been implicated in the devel...
ORGANISM(S): Rattus Norvegicus 
2020-10-27 | PXD020777 | panorama
ProteomicsAssessment of Kinome-wide Rewiring Upon Picornavirus Infection
Picornaviridae is a large family of single-stranded positive RNA viruses that can infect both humans and animals. These include the enteroviruses (e.g. poliovirus, coxsackievirus and rhinoviruses) as well as the cardioviruses (e.g. encephalomyocarditis virus (EMCV)). Picornaviruses have evolved to i...
ORGANISM(S): Homo Sapiens 
PXD046598 | panorama
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