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TranscriptomicsHIF orchestrated metabolic shift confers protection against Acute Kidney Injury (AKI)
Renal hypoxia is widespread in acute kidney injury (AKI) of various aetiologies. Hypoxia adaptation, conferred through the hypoxia-inducible factor (HIF), appears to be insufficient. Here we show that HIF activation in renal tubules through Pax8-rtTA-based inducible knockout of von Hippel-Lindau pro...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-44925 | biostudies-arrayexpress
GenomicsGenome-wide transcriptome analysis of VC and VHL-KO Caki-1 cells.
Genome-wide transcriptome analysis of VC and VHL-KO Caki-1 cells.
PRJNA805226 | ENA
TranscriptomicsHypoxia-inducible factors enhance CD8+ T cell effector responses to persistent antigen.
Cytolytic activity by CD8+ cytotoxic T lymphocytes (CTL) is a powerful tactic in the elimination of intracellular pathogens and tumor cells. The destructive capacity of CTL is progressively dampened during chronic infection - yet the environmental cues and molecular pathways controlling immune “exha...
ORGANISM(S): Mus musculus 
2013-09-29 | E-GEOD-50158 | biostudies-arrayexpress
ProteomicsProteomic profiling of tendon-specific VHL knockout and VHL-dependent double knockout mouse tail tendon fascicles
This study investigates how chronic activation of HIF1α in tendon cells drives pathological extracellular matrix (ECM) remodeling and whether these changes can be modulated by genetic rescue strategies. Using tendon cell-specific deletion of Vhl (Scx;Vhl) in mice, which stabilizes HIF1α, we observed...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-24 | PXD069135 | Pride
Lc-msms Vegfa ko Mouse Hif1a ko Tendon Vhl ko 
GenomicsGenetic vulnerabilitis study in VHL mutant cells
Genetic vulnerabilitis study in VHL mutant cells
PRJNA880165 | ENA
TranscriptomicsGenome-wide transcriptome analysis of VC and VHL-KO Caki-1 cells.
To compare the transcriptomic changes mediated by VHL knockout in Caki-1 cells, we carried out the next-generation sequencing (NGS)-derived transcriptomic profiling. We found significant enrichment of gene signatures involving IFNa/b signaling in VHL-KO Caki-1 cells compared to control cells. Our an...
ORGANISM(S): Homo sapiens 
2024-08-10 | GSE196509 | GEO
ProteomicsLabel-free quantitative proteomics of Achilles and tail tendon fascicles from WT and VHL KO mice
Tendon integrity depends on controlled extracellular matrix production and adaptation to mechanical load. Dysregulated hypoxia-inducible factor 1α (HIF1α) signaling has been linked to human tendon disease. To investigate the effects of chronic HIF1α activation and to compare responses between load-b...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-24 | PXD069118 | Pride
Lc-msms Mouse Tendon Vhl ko 
TranscriptomicsRNA-sequencing shows the changes on transcriptomes after deletion of Setd2 in VHL deficient mice.
To explore the possible role of SETD2 in renal fibrosis formation, we generated VHL-KO and VHL-KO; SETD2-KO mice with a transgenic Ksp1.3/Cre mouse line. To get an insight into the mechanism of how SETD2 deletion promotes renal fibrogenesis in the absence of VHL, we performed RNA-seq using the renal...
ORGANISM(S): Mus musculus 
2022-10-19 | GSE213922 | GEO
GenomicsRNA-sequencing shows the changes on transcriptomes after deletion of Setd2 in VHL deficient mice.
RNA-sequencing shows the changes on transcriptomes after deletion of Setd2 in VHL deficient mice.
PRJNA883184 | ENA
GenomicsHIFa isoform specific activation drives cell-type specificity of VHL-associated oncogenesis
HIFa isoform specific activation drives cell-type specificity of VHL-associated oncogenesis
PRJNA1190947 | ENA
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