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ProteomicsThe multimerization pathway of the glucocorticoid receptor
The glucocorticoid receptor (GR/NR3C1), a ligand-activated transcription factor belonging to the nuclear receptor (NR) superfamily, is vital for life. Like other NRs, GR features an intrinsically disordered N-terminal domain (NTD) followed by a highly conserved DNA-binding domain (DBD) and a hormone...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD065782 | Pride
Glucocorticoid receptor Transcription factor Glucocorticoid resistance Steroid receptor Nuclear receptor Quaternary structure Homodimerization 
ProteomicsStructure of the Homodimeric Androgen Receptor Ligand-Binding Domain
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the etiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility, and prostate cancer (PCa). Here, we show that dimerization of AR ligand-b...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005575 | Pride
Ar Cross-linking 
ProteomicsAlterations in the abundance of protamine proteoforms related to sperm chromatin packaging, obesity, and age in men with unexplained infertility
Protamine1 (P1) and Protamine 2 family (P2) are the most relevant nuclear proteins in the male gamete since are necessary to compact and protect the paternal genome. Human and mouse sperm contain a complex population of protamine proteoforms, which raises the interest to decipher whether it responds...
ORGANISM(S): Homo sapiens (Human) 
2025-04-25 | PXD049367 | Pride
Proteoforms Top-down proteomics Protamines Male infertility Sperm Chromatin 
ProteomicsEndocytic Turnover of Endothelial Cell-Membrane Proteins as a Driver of Blood Brain Barrier Specialization and Dysfunction
The blood-brain barrier (BBB), formed primarily by specialized brain endothelial cells (BEC), exerts essential functions for proper brain activity, including nutrient transport, signal transduction, immune cell transmigration and pathogen restriction. While these functions are known to be regulated ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-15 | PXD067112 | Pride
Blood-brain barrier Brain endothelial cells Endocytic turnover rate 
ProteomicsTargeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Recent drug discovery breakthroughs led to the approval of KRASG12C inhibitors in lung adenocarcinoma (LUAD). Unfortunately, clinical responses remain limited due to rapid resistance onset. Proteolysis-targeting chimeras (PROTACs) have emerged as promising alternatives to traditional inhibition. How...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-13 | PXD058734 | Pride
Mouse models Targeted protein degradation in vivo Resistance Llung adenocarcinoma Kras Protacs 
ProteomicsEndogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy
Mitofusin-1 (MFN1) and Mitofusin-2 (MFN2) are key players in mitochondrial fusion, endoplasmic reticulum (ER)-mitochondria yuxtaposition, and autophagy. However, the mechanisms by which these proteins participate in these processes remain poorly understood. To better understand their functions, we s...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD043168 | Pride
Mitophagy Autophagy Membrane contact sites Interorganelle communication Endosomes Mitochondrial dynamics 
ProteomicsQuantification of histone H1 subtypes using targeted proteomics
Histone H1 is involved in the regulation of chromatin structure. Human somatic cells express up to seven subtypes: H1.0, H1.1-H15, and H1X. The variability in the proportions of somatic H1s (H1 complement) is one evidence supporting their functional specificity. Alterations in the protein levels of ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD050243 | Pride
Imatinib resistance Chronic myeloid leukemia Functional differentiation Cancer biomarker Parallel reaction monitoring Histone h1 
ProteomicsProtamine characterization by top-down proteomics: Boosting proteoform identification with DBSCAN
Protamines replace histones as the main nuclear protein in sperm cells having a crucial role in compacting the paternal genome. Human spermatozoa contain the protamine 1 (P1) and the family of protamine 2 (P2) proteins. Alterations in protamine PTMs or on the P1/P2 ratio could be associated with mal...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD024405 | Pride
Male infertility  sperm  protamine  lc-ms/ms  top down proteomics  proteoform  post-translational modifications  bioinformatics  dbscan. 
ProteomicsProteomic tools for the quantitative analysis of artificial peptide libraries: detection and characterization of target-amplified PD-1 inhibitors
We report a quantitative proteomics data analysis pipeline which, coupled to protein-directed dynamic combinatorial chemistry (DDC) experiments, enables the rapid discovery and direct characterization of protein-protein interaction (PPI) modulators. A low-affinity PD-1 binder was incubated with a li...
ORGANISM(S): Homo sapiens (Human) 
2022-04-19 | PXD028412 | Pride
Medicinal chemistry Drug discovery Mass spectrometry 
ProteomicsGlycopeptide identification by LC-MS/MS
Automatic and rapid identification of glycopeptides by nano-uplc-ltq-ft-ms and proteomic search engine
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2016-12-23 | PXD003578 | Pride
Glycopeptide Lc-ms/ms Byonic 
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