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MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsDetection of virulence and antibiotic resistance gene families
Emerging known and unknown pathogens create profound threats to public health. Platforms for rapid detection and characterization of microbial agents are critically needed to prevent and respond to disease outbreaks. Available detection technologies cannot provide broad functional information about ...
ORGANISM(S): Staphylococcus aureus subsp. aureus Mu50 
2008-04-02 | E-GEOD-11010 | biostudies-arrayexpress
TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum 
2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress
TranscriptomicsIdentification of MglA-regulated genes reveals novel virulence factors in F. tularensis
The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are...
ORGANISM(S): Francisella tularensis 
2010-07-01 | E-GEOD-5468 | biostudies-arrayexpress
ModelsiRP1443REG - Ralstonia solanacearum GMI1000 Virulence regulatory network
We reconstructed the Virulence Regulatory Network (VRN) of R. solanacearum strain GMI1000 by collecting bibliographical information based on genetic and genomic studies, including three transcriptomic studies. The reconstructed R. solanacearum VRN comprises 712 genes including 29 genes coding for tr...
2023-11-10 | MODEL1710170000 | BioModels
TranscriptomicsVirulence differences in Toxoplasma mediated by amplification of polymorphic pseudokinases.
The population structure of Toxoplasma gondii includes three highly prevalent clonal lineages, types I, II, and III, which differ greatly in virulence in the mouse model. Previous studies have implicated a family of serine threonine protein kinases found in rhoptries (ROPs) as important in mediatin...
ORGANISM(S): Toxoplasma gondii 
2011-05-03 | E-GEOD-24905 | biostudies-arrayexpress
ProteomicsThe Cryptosporidium signaling kinase CDPK5 plays an important role in male gametogenesis and parasite virulence
The protozoan parasite Cryptosporidium is a leading cause of diarrhea associated mortality in young children. The parasite’s lifecycle involves a highly coordinated and timely progression from asexual proliferative to sexual stages leading to formation of the transmissible oocyst. Underlying molecul...
ORGANISM(S): Cellular Organisms 
2024-06-04 | PXD051082 | JPOST Repository
TranscriptomicsTranscription profiling of Franscisella tuarensis to identify new virulence factors utilized by F. tularensis which causes the zoonotic disease tularemia
The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo and this ability is essential for pathogenesis. The transcription factor MglA is required for expression of several Francisella genes that are...
ORGANISM(S): Francisella tularensis 
2006-10-19 | E-SMDB-3741 | biostudies-arrayexpress
TranscriptomicsThe effect of IAN on P. aeruginosa virulence
Intercellular signal indole and its derivative hydroxyindoles inhibit Escherichia coli biofilm and diminish Pseudomonas aeruginosa virulence. However, indole and bacterial indole derivatives were unstable in microbial community due to the widespread of diverse oxygenases that could quickly degrade ...
ORGANISM(S): Pseudomonas aeruginosa 
2011-02-20 | E-GEOD-21508 | biostudies-arrayexpress
TranscriptomicsTranscriptomic characterization of a virulence-deficient phosphatidylcholine-negative Agrobacterium tumefaciens mutant
To learn more about the global effects of phosphatidylcholine (PC)-deficiency in A. tumefaciens, we performed transcriptomic studies comparing the wild type and a PC-deficient DpmtA Dpcs mutant. We expanded the number of affected virulence genes and showed that the loss of PC was correlated with alt...
ORGANISM(S): Agrobacterium tumefaciens str. C58 
2010-04-07 | E-GEOD-21223 | biostudies-arrayexpress
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