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TranscriptomicsRNA of murine macrophages and neutrophils treated with LPS and VISTA
V-domain immunoglobulin suppressor of T-cell activation (VISTA) has emerged as a unique immunoregulatory receptor on cells of the myeloid lineage. Agonizing VISTA on myeloid cells has recently been demonstrated to have a profound effect on dampening inflammatory responses. VISTA has been proposed to...
ORGANISM(S): Mus musculus 
2022-12-02 | E-MTAB-10856 | biostudies-arrayexpress
ProteomicsLRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
Cancer immunotherapies boost antitumor immunity and improve the survival of cancer patients. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an immune 20 checkpoint target but presents elusive signaling mechanisms. We report a novel VISTA binding partner, Leucine-Rich Repeats and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050084 | Pride
Bottom up proteomics Proximity labelling Cancer 
ProteomicsIdentification of FLAG-VISTA binding proteins in mesothelioma
FLAG-VISTA expressed in Y-MESO-14 or NCI-H2373 cells was immunoprecipitated with anti-FLAG antibody. Parental cells were used for control samples. Immunoprecipitates were analyzed by LC-MS/MS.
ORGANISM(S): Homo Sapiens (human) 
2026-08-24 | PXD071509 | JPOST Repository
ProteomicsVISTA+ Neutrophils Enhance Chemoresistance in High-Grade Serous Ovarian Cancer by Suppressing CD8+ T Cells Infiltration
Platinum-based chemoresistance is a primary cause of treatment failure and unfavorable prognosis in high-grade serous ovarian cancer (HGSOC). Although inflammation plays a critical role in chemoresistance, in which neutrophils (Neus) emerge as potent inflammatory regulator across various cancers, th...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD062992 | Pride
Vista Cd8+ t cell Neutrophils High-grade serous ovarian cancer Chemoresistance 
GenomicsRole of VISTA in ILC2-mediated airway hyperreactivity
Role of VISTA in ILC2-mediated airway hyperreactivity
PRJNA1134271 | ENA
TranscriptomicsRole of VISTA in ILC2-mediated airway hyperreactivity
Type-2 innate lymphoid cells (ILC2s) play a pivotal role in the development of airway hyperresponsiveness (AHR). However, the regulatory mechanisms governing ILC2 function remain inadequately explored. This study uncovers V-domain Ig suppressor of T cell activation (VISTA) as an inhibitory immune ch...
ORGANISM(S): Mus musculus 
2025-02-18 | GSE271999 | GEO
ProteomicsOrganelle remodeling across infection time: Cytomegalovirus-host protein interactions viewed through the lens of Inter-ViSTA
Nearly all biological processes rely on the finely-tuned coordination of protein interactions across cellular space and time. Accordingly, generating protein interactome datasets has become routine in biological studies, yet effectively interpreting these datasets remains computationally challenging...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD017163 | Pride
Ap-ms Ul37 Hcmv Pul37x1 Ppi 
TranscriptomicsVISTA re-programs macrophage biology through the combined regulation of tolerance and anti-inflammatory pathways 
1) BMDMs treated with anti-VISTA under tolerizing and immunizing conditions. 2) Time course analysis of anti-VISTA-induced alterations in human monocytes after anti-VISTA treatment. 3) Time course analysis of anti-VISTA-induced alterations in BMDMs after anti-VISTA treatment. 4) Single cell ATAC-seq...
ORGANISM(S): Homo sapiens Mus musculus 
2020-09-05 | GSE157518 | GEO
GenomicsRNA of murine macrophages and neutrophils treated with LPS and VISTA
RNA of murine macrophages and neutrophils treated with LPS and VISTA
PRJEB46993 | ENA
TranscriptomicsVISTA is an activating receptor that binds the proteoglycan Syndecan-2 on monocytes.
As indicated by its name, V-domain Ig suppressor of T cell activation (VISTA) is thought to primarily serve as an inhibitory protein that limits immune responses. VISTA-antibodies can dampen the effects of several concomitantly elicited activation signals including T cell receptor (TCR) and Toll-lik...
ORGANISM(S): Homo sapiens 
2021-05-04 | GSE173747 | GEO
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