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ProteomicsTracking prostate carcinogenesis over time through urine proteome profiling in an animal model: an exploratory approach
The urgent need for new tools for the early diagnosis of prostate cancer (PCa) has prompted us to investigate the proteomic profile of urine during the course of prostate carcinogenesis. Using an established animal model of prostate adenocarcinoma, we performed a comprehensive analysis of the proteo...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD034432 | Pride
Prostate adenocarcinoma Cadherin-2 Urinary proteomics Aging Gelc-ms/ms Enolase-1 Retinol-binding protein 4 
ProteomicsUbiquitome profiling uncovers disturbed mitochondrial remodeling as an outcome of doxorubicin-induced cardiotoxicity in old mice
The urgent need to understand the molecular modulation associated with chronic cardiotoxicity of doxorubicin (DOX) has prompted us to investigate the ubiquitome profile of aged cardiac muscle. Using old CD-1 male mice administered with a DOX dosage established to induce cardiotoxicity, we performed ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD048078 | Pride
Mitochondrial dynamics Old Chronic cardiotoxicity Ubiquitination Anticancer therapy Cardio-oncology 
ProteomicsUrinary proteome related to coronary artery disease and aortic stenosis
Coronary artery disease (CAD) and the frequently coexisting aortic valve stenosis (AS) are the heart diseases accounting for the highest proportion of cardiac surgeries. Routine biomarkers for an earl detection of either of these atherosclerotic-rooted conditions would be important to anticipate the...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2022-12-18 | PXD036800 | Pride
Human Aortic valve stenosis Urine Molecular marker Coronary artery disease 
ProteomicsCharacterization of the human urine proteome in Prostate Cancer
Prostate cancer (PCa) is one of the most prevalent cancers among men and the fifth leading cause of cancer-related death in men. Currently, PCa suspicion is based on abnormal digital rectal examination and/or raised PSA serum levels, with prostate needle biopsy being required for a definitive diagno...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD017902 | Pride
Human  proteome  urine  prostate cancer 
ProteomicsPericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling
Patients with aortic stenosis are often indicated to aortic valve replacement to relief pressure overload. After surgery, patients experience a myocardial response commonly known as reverse remodeling, where structural and functional recovery are expected. Notwithstanding, some patients exhibit an i...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD015607 | Pride
Human Coronary artery disease Aortic stenosis Pericardial fluid Reverse remodeling 
ProteomicsCharacterization of the human myocardial phosphoproteome in aortic stenosis patients with complete or incomplete reverse remodeling
Aortic valve stenosis (AS) is a serious condition characterized by the progressive narrowing of the aortic valve, associated with a continuous rise in left ventricle pressure overload. Currently, aortic valve replacement (AVR) remains as the definitive treatment for AS, since an immediate dissipatio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD015498 | Pride
Human  phosphoproteome  myocardium  aortic stenosis  reverse remodeling 
ProteomicsCharacterization of the human myocardial proteome in aortic stenosis patients with complete or incomplete reverse remodeling
Aortic valve stenosis (AS) is a serious condition characterized by the progressive narrowing of the aortic valve, associated with a continuous rise in left ventricle pressure overload. Currently, aortic valve replacement (AVR) remains as the definitive treatment for AS, since an immediate dissipatio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD015497 | Pride
Human  proteome  myocardium  left ventricle  aortic stenosis  reverse remodeling 
ProteomicsProteomic profile of the early transition from naïve to primed pluripotency in mouse ES cells
We describe here the proteome of mouse embryonic stem cells growth in complete media (KSR, LIF/2i) or media without 2i for 24h and 48h.
ORGANISM(S): Mus musculus (Mouse) 
2025-06-23 | PXD033005 | Pride
Mouse  cultures Stem cells 
ProteomicsA Standard Operating Procedure for Protein Extraction from Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications
The identification of putative biomarkers for predicting abdominal aortic aneurysm (AAA) progression can be achieved through proteomic strategies, particularly with shotgun proteomics. However, the heterogeneity of AAA tissue poses challenges for tissue homogenization and protein extraction, comprom...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060417 | Pride
Abdominal aortic aneurysm  aortic tissue homogenization  protein extraction  proteomics  sop 
ProteomicsThe The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-induced CytotoxicitySecretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-induced Cytotoxicity
Breast cancer remains one of the leading causes of death in women, being the chemotherapeutic agent doxorubicin (Dox) among the most widely standard chemotherapy options for its treatment. However, its effective use has been severely limited owing to its well-documented cardiotoxic side effect that ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025633 | Pride
Human  breast cancer  proteome  mesenchymal stem/stromal cells  secretome  3d cultures 
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