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ProteomicsHUVEC cell extracts for the investigation of collagen-induced cell signalling
We demonstrated that an abundant Collagen type I alpha 1-derived peptide inhibited collagen type I-induced endothelial cell migration in Human Umbilical Vein Endothelial Cells. We then applied mass spectrometry based proteomics to investigate the potential signalling pathways induced by collagen typ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-12 | MSV000097296 | MassIVE
ProteomicsProteomics analysis of Formalin Fixed Paraffin Embedded tissues in the investigation of prostate cancer
As proteins represent cell function, proteomic analysis of prostate tissues may elucidate the mechanisms of prostate cancer (PCa) progression. To that end, formalin-fixed paraffin-embedded (FFPE) tissues are valuable resources, but associated with large analytical difficulties due to protein cross-l...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-11-15 | PXD015981 | Pride
Prostate cancer Human Orbitrap elite Ffpe tissue Ff tissue Thermo q exactive Mouse 
ProteomicsUrinary Glycosylated IGF2 peptides in association with CKD
Chronic kidney disease (CKD) is prevalent in 10% of world’s adult population, with Estimated Glomerular filtration rate (eGFR) and albuminuria employed in diagnosis. Role of protein glycosylation in causal mechanisms of CKD progression is largely unknown. Aim of this study was to identify urinary O-...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039829 | Pride
Ckd  egfr  post translational modifications  ptms  glycosylation  urine  peptidomics  glyco-peptide  igf2 
ProteomicsInvestigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in the later stages of CKD
The interplay of gut microbiota with the kidney system, characteristic to reduced kidney function and increased concentrations of urea in gut; in turn increases bacterial urease activity and generation of uremic toxins. Knowledge on these underlying bidirectional molecular mechanisms is nevertheless...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD048778 | Pride
Butyrate Ckd Inflammation Gut Bioinformatics Fecal Proteomics Lc-ms/ms 
ProteomicsLC-MS/MS based proteomics analysis of decellularized and non-decellularized mouse kidney tissue samples
Two C57Bl6/J male mice were sacrificed by injecting 200 microliters of the lethal anaesthetic Dolethal. Kidneys were perfused with Dulbeccos Phosphate Buffered Saline, dissected, decapsulated and weighted. Kidneys were decellularized using 3 freeze-thaw cycles (freezing at -80C, 30 minute long thawi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-07 | MSV000094031 | MassIVE
ProteomicsComparative analysis of label-free and 8-plex iTRAQ approach for quantitative tissue proteomic analysis
MS-based approaches have been successfully utilized for the comprehensive characterization of the cell proteome. However, in the case of quantitative proteomics the open question still remains, which quantification method is more suitable for identification of proteins with the altered abundance, pa...
ORGANISM(S): Homo sapiens (Human) 
2015-09-09 | PXD002170 | Pride
Lc-ms/ms Bladder cancer Tissue proteomics Label-free Itraq 
ProteomicsProteomic analysis of prostate cancer FFPE samples reveals markers of disease progression and aggressiveness
Prostate cancer (PCa) is the second most common cancer in men. Diagnosis and risk assessment are widely based on serum Prostate Specific Antigen (PSA) and biopsy which have low accuracy. Towards the discovery of biomarkers for better patient stratification, we performed proteomic analysis of Formali...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-22 | MSV000089707 | MassIVE
ProteomicsCardioprotection by selective SGLT2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?
Major clinical trials with sodium glucose co-transporter-2 inhibitors (SGLT-2i) exhibit protective effects against heart failure events, whereas inconsistencies regarding the cardiovascular death outcomes are observed. Therefore, we aimed to compare the selective SGLT-2i empagliflozin (EMPA), dapagl...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-17 | MSV000088582 | MassIVE
ProteomicsProteomic dataset of exosomes derived from fetal mesenchymal stromal cells
The raw files of the proteomics dataset are N=18 and a brief description of the files is shown below: AF1 raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 1 AF2.raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 2 AFA1.raw: exosomes derived from Amniotic Fl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092848 | MassIVE
ProteomicsProteomic analysis of bone marrow CD138+ cells to identify proteins associated with the response of multiple myeloma patients to commonly used therapeutic regimens.
Multiple Myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs resistance mechanisms are involved in the failure of therapies to eradicate the disease. This study aims to identify proteins significantly impacting MM patients' response to commonly used thera...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-04-02 | MSV000097497 | MassIVE
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