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ProteomicsInteractome of the -subunit of L-type voltage-gated calcium channels in adult cardiomyocytes
In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction coupling. LTCCs are heteromultimeric proteins compose...
ORGANISM(S): Rattus rattus (Black rat) 
2021-12-14 | PXD021375 | Pride
Dstorm Ca2+ influx Proteomics L-type voltage-gated calcium channels (ltccs) Nano-environments of cav2 Pull-down Cardiomyocytes 
ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
ProteomicsCrotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity
Neurotoxicity following South American Crotalus rattlesnake bite is primarily caused by crotoxin, the most abundant component in their venom. Despite the central role of volt-age-gated calcium channels (CaV) in neurotransmission, direct targetability by crotoxin has been poorly explored. Crotoxin is...
ORGANISM(S): Crotalus vegrandis 
2026-02-02 | PXD070916 | Pride
UnknownStructural biology of voltage-gated calcium channels.
Not available
S-EPMC10761187 | biostudies-literature
UnknownVoltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.
Not available
S-EPMC5043047 | biostudies-literature
UnknownCalmodulin regulation (calmodulation) of voltage-gated calcium channels.
Not available
S-EPMC4035741 | biostudies-literature
UnknownMore than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
Not available
S-EPMC8205089 | biostudies-literature
UnknownOptogenetic Control of Voltage-Gated Calcium Channels.
Not available
S-EPMC6032918 | biostudies-literature
UnknownSelective fluorophore-assisted light inactivation of voltage-gated calcium channels.
Not available
S-EPMC3431587 | biostudies-literature
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