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ProteomicsProteomic Analysis of Carotid Artery Plaques With and Without Vulnerable Features on Magnetic Resonance Angiography with Vessel Wall Imaging: A Pilot Study
Single-center, cohort study of plaques identified with and without vulnerable features on magnetic resonance angiography with vessel wall imaging. Proteomic analysis of these plaques demonstrates different protein composition. These proteins may be used for early detection and intervention or as pha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052120 | Pride
Lc-msms Human carotid plaques Lcm/ffpe 
ProteomicsVulnerable Carotid Artery Plaques Exhibit Proteolysis, Metabolic Reprogramming and Inflammation
Carotid plaque vulnerability is a current feature that aids in the decision making for ischemic stroke risk prevention. Proteomic analysis of plaque tissue can reveal molecular indicators of instability that complement imaging findings. We sought to identify a proteomic signature distinguishing vuln...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068148 | Pride
Carotid artery disease Proteomics Stroke Vulnerable features Risk stratification 
TranscriptomicsCharacterization of human embryonic stem cells with features of neoplastic progression
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers,...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13995 | biostudies-arrayexpress
TranscriptomicsIncreased Human like Alzheimer features in a Novel Mouse Model with Oxidative DNA Repair Dysfunction
The decline of cognitive function is a feature of normal human aging and is exacerbated in AlzheimerM-bM-^@M-^Ys disease (AD). DNA repair declines in brain cells during normal aging and even more so in AD. Here we show that experimental reduction in levels of the base excision repair enzyme, DNA ...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-60911 | biostudies-arrayexpress
UnknownAssessment of coronary computed tomography angiography-derived plaque features in the diagnosis of optical coherence tomography-defined vulnerable plaques.
Not available
S-EPMC11948381 | biostudies-literature
UnknownHeart rate lowering treatment leads to a reduction in vulnerable plaque features in atherosclerotic rabbits.
Not available
S-EPMC5480870 | biostudies-literature
UnknownProteomic analysis of carotid artery plaques with and without vulnerable features on magnetic resonance angiography with vessel wall imaging: a pilot study.
Not available
S-EPMC11874813 | biostudies-literature
UnknownPericoronary Adipose Tissue Radiomics from Coronary Computed Tomography Angiography Identifies Vulnerable Plaques.
Not available
S-EPMC10045206 | biostudies-literature
TranscriptomicsMulti-platform approach for plaque-derived biomarkers for the vulnerable plaque. Challenges and promises.
Plaque rupture and subsequent thrombus formation is responsible for the majority of clinical complications of atherosclerosis and nonetheless our understanding of what underlies plaque vulnerability and rupture is still sparse and mostly deductively based on animal models and in vitro studies. We ad...
ORGANISM(S): Homo sapiens 
2014-05-17 | E-MTAB-2055 | biostudies-arrayexpress
UnknownPopulation genetic structure and connectivity of deep-sea stony corals (Order Scleractinia) in the New Zealand region: Implications for the conservation and management of vulnerable marine ecosystems.
Not available
S-EPMC5680633 | biostudies-literature
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