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ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
ProteomicsGlobal and specific mechanisms stimulate mistranslation in cancer
In the context of anti-tumor immunity, activated T cells secrete interferon-gamma (IFNγ) to induce indoleamine 2,3-dioxygenase (IDO1) in the target cancer cells. High IDO1 levels deplete tryptophan, leading to aberrant protein production due to tryptophan to phenylalanine codon reassignments (W>F su...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD060710 | Pride
Lc-msms Anti-tumor immunity W>f substitutants Ftsj1 Neo-epitopes 
UnknownTryptophan depletion results in tryptophan-to-phenylalanine substitutants.
Not available
S-EPMC8942854 | biostudies-literature
UnknownHyperactivation of mTOR/eIF4E Signaling Pathway Promotes the Production of Tryptophan-To-Phenylalanine Substitutants in EBV-Positive Gastric Cancer.
Not available
S-EPMC11425274 | biostudies-literature
ProteomicsTryptophan depletion provokes the production and presentation of in-frame tryptophan to phenylalanine substitutions
Activated T cells secrete interferon-gamma (IFN) that triggers an intra-cellular tryptophan shortage through the activation of the Indoleamine 2,3-Dioxygenase 1 (IDO1) enzyme. Surprisingly, we here show that despite tryptophan depletion, in-frame protein synthesis bypassing tryptophan codons contin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-23 | PXD028921 | Pride
Cancer Tryptophan depletion Amino acid substitution Lc-ms/ms 
OtherGlobal and specific mechanisms stimulate mistranslation in cancer
Tryptophan codon-specific mistranslation, in the form of ribosomal frameshifting and tryptophan-to-phenylalanine (W>F) codon reassignments (substitutants), is induced in cancer cells by the limiting level of tryptophan imposed by anti-tumor immunity. While frameshifting is driven by the oncogenic MA...
ORGANISM(S): Homo sapiens 
2026-08-26 | GSE289861 | GEO
GenomicsGlobal and specific mechanisms stimulate mistranslation in cancer
Global and specific mechanisms stimulate mistranslation in cancer
PRJNA1225211 | ENA
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