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ProteomicsStoichiometry of the bacterial type III secretion export apparatus
Bacterial type III secretion systems are cell envelope-spanning effector protein-delivery machines essential for colonization and survival of many Gram-negative pathogens and symbionts. The membrane-embedded core unit of these secretion systems is termed needle complex. The needle complex is compose...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2016-02-25 | PXD003113 | Pride
Mass spectrometry Stoichiometry Salmonella Type iii secretion 
ProteomicsSseF-SscB Interaction - Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems
Bacterial type III secretion systems are able to secrete membrane proteins. In this project we could show that cognate T3SS chaperones are able to bind to the transmembrane segments of T3SS substrates to avoid erroneous targeting to the bacterial inner membrane. Here, we studied the Salmonella SPI-2...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2018-10-16 | PXD010470 | Pride
Salmonella Pbpa Sscb In vivo photocrosslinking Ssef Type iii secretion systems 
ProteomicsSpaP and SpaR interaction partner identification
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called needle com...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2016-11-29 | PXD005028 | Pride
Spar Spap T3ss Photocrosslinking 
ProteomicsAnalysis of secretion of transmembrane effectors by the type IV b secretion system of Legionella pneumophila
In order to promote intracellular survival and infection, Legionella spp. translocate hundreds of effector proteins into eukaryotic host cells using a type IV b protein secretion system (T4bSS). T4bSS are well known to translocate soluble as well as transmembrane domain-containing effector proteins ...
ORGANISM(S): Legionella pneumophila 
2024-10-15 | PXD050153 | Pride
Type iv secretion system Effector Legionella Bacterial inner membrane 
ProteomicsElucidation of the substrate specificity of the ABC transporter Tba uncovers an unsuspected role in the biosynthesis of glycopeptide antibiotics
In this project, the proximal proteins of the balhimycin transporter Tba in A. balhimycina were investigated in order to elucidate potential interaction partners. Tba is an ABC transporter, which is co-encoded with biosynthetic enzymes in the biosynthetic gene cluster of the glycopeptide antibiotic ...
ORGANISM(S): Bacteria Amycolatopsis balhimycina 
2025-05-07 | PXD054387 | Pride
Amycolatopsis balhimycina Glycopeptide antibiotics Balhimycin Abc transporter 
MetabolomicsGenotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear genome, and anterograde signalling to mitochondria. All these interactions have the potential to influence the freque...
2018-11-07 | MTBLS724 | MetaboLights
UnknownMedicaid Expansion Increased Preconception Health Counseling, Folic Acid Intake, And Postpartum Contraception.
Not available
S-EPMC7688246 | biostudies-literature
UnknownPersistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling.
Not available
S-EPMC7881115 | biostudies-literature
UnknownJuvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood.
Not available
S-EPMC12000401 | biostudies-literature
UnknownNear Infrared Fluorescent Nanoplatform for Targeted Intraoperative Resection and Chemotherapeutic Treatment of Glioblastoma.
Not available
S-EPMC7438253 | biostudies-literature
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