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ProteomicsHOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. We demonstrated that the transcription factor, HOXC6, was overexpressed in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis. HOXC6 transcriptionally activated the tumor-pr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-31 | PXD041238 | Pride
Pancreatic cancer Hoxc6 Tumor growth Msk1 Metastasis 
ProteomicsHOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. We demonstrated that the transcription factor, HOXC6, was overexpressed in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis. HOXC6 transcriptionally activated the tumor-pr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-31 | PXD041239 | Pride
Pancreatic cancer Hoxc6 Tumor growth Msk1 Metastasis 
ProteomicsIdentification of novel LIMK2 phosphorylation substrates
Breast cancer is the most common and a lethal form of cancer diagnosed in women worldwide. Although, effective treatment options for primary tumors are available, the majority of breast cancer-related deaths is caused by invasion of cells from primary tumor results in metastatic progression. Here we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD008246 | Pride
Breast cancer Limk2 Phosphorylation Invasion 
TranscriptomicsmiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-39983 | biostudies-arrayexpress
TranscriptomicsRegulators of NRAS-mediated transformation and melanoma tumor maintenance
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-69933 | biostudies-arrayexpress
TranscriptomicsOncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells
Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role of this silencing in oncogenesis is not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces silencing...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-GEOD-39292 | biostudies-arrayexpress
TranscriptomicsPEA15 regulates the DNA damage induced cell cycle checkpoint and oncogene-directed transformation
Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the l...
ORGANISM(S): Homo sapiens 
2014-04-07 | E-GEOD-39297 | biostudies-arrayexpress
TranscriptomicsTranscriptional targets of oncogenic RAS proteins that mediate their ability to induce cellular transformation
Mutations in the NRAS oncogene are present in up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, and knockdown of IFI6 resulted in DNA replicat...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-62827 | biostudies-arrayexpress
TranscriptomicsmiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-39294 | biostudies-arrayexpress
UnknownLoss of EHMT2 Enhances NK Cell-Driven Anti-Tumor Immunity through TGF-β1 Suppression
Not available
S-SCDT-10_1038-S44321-025-00357-6 | biostudies-other
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