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Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of monoclonal light chain (LC) and its fragments containing variable (VL) and portions of constant (CL) domains. AL patients feature either monoclonal free LCs circulating as covalent and noncovalent h...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD055570 | Pride
Immunological proteins are major disease targets and the majority remain undrugged. Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation, especially in the context of the macrophage cytokine response.1 Here, we develop a strategy for syst...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD055006 | Pride
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