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ProteomicsDynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC) and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass spectrometry-based proteomics to identify readers for mC and hmC in mouse embry...
ORGANISM(S): Mus musculus (Mouse) 
2013-02-26 | PXD000143 | Pride
5-hydroxymethylcytosine Differentiation Stem cells Chromatin readers Quantitative mass spectrometry 
ProteomicsQuantitative proteomics identifies ML111 as a cell-cycle inhibitor
We used quantitative mass spectrometry to analyze the effect of ML111 on the whole proteome of SK-N-MC cells. Results: ML111 treatment results in the accumulation of APC/C substrates suggesting that ML111 disrupts the cell cycle at or before the mitotic spindle assembly checkpoint.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086599 | MassIVE
UnknownAlterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle.
Not available
S-EPMC3132216 | biostudies-literature
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
UnknownNitroglycerin challenge identifies microcirculatory target for improved resuscitation in patients with circulatory shock.
Not available
S-EPMC11369126 | biostudies-literature
UnknownOptimization of a Plasmodium falciparum circumsporozoite protein repeat vaccine using the tobacco mosaic virus platform.
Not available
S-EPMC7022184 | biostudies-literature
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsMm_mChmC_DynamicReader
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
ORGANISM(S): Mus Musculus 
2013-12-31 | PAe004058 | PeptideAtlas
ProteomicsCaspase-8’s non-apoptotic role is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.
Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Programmed cell death is known to drive inflammation, however, its relevance in the pathogenesis of severe COVID-19 is unclear. Using a combination of gene-targeted murine models and transcriptomic approaches we found that...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-20 | PXD057656 | Pride
Sars-cov-2  caspase-8  inflammation  flip  covid-19  cytokines 
UnknownPhase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.
Not available
S-EPMC2669163 | biostudies-literature
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