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ProteomicsLRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses
Cancer immunotherapies boost antitumor immunity and improve the survival of cancer patients. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an immune 20 checkpoint target but presents elusive signaling mechanisms. We report a novel VISTA binding partner, Leucine-Rich Repeats and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050084 | Pride
Bottom up proteomics Proximity labelling Cancer 
ProteomicsNegative regulation of Type I IFN signaling by phosphorylation of STAT2 on T387
The samples were derived from STAT2 IP experiments from human fibrosarcoma cells. This experiment involved the transfection of cells with a flag tagged STAT2 and the goal of these experiments is to identify STAT2 binding partners.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005008 | Pride
Stat2 Phosphorylation 
ProteomicsInhibition of KDEL receptors remodels the tumor microenvironment for T cell independent tumor regression
Tumor immunotherapy is supported by low-grade inflammatory conditions at the microenvironment, triggered by immunogenic cell death (ICD). However, ICD is dampened when tumors acquire resistance, affecting immune recognition. KDEL receptors (KDELRs), through a retrograde Golgi-to-ER transport, preven...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD072994 | Pride
Kdel protein Er stress Tumor microenvironment 
ProteomicsQuantitative profiling of protein sulfhydrome by the BTA-TMT
The redox-based modification of cysteine residues in proteins regulates their function in many biological processes. The gas molecule H2S has been shown to sulfhydrate redox sensitive cysteine residues resulting in an H2S-modified proteome known as the sulfhydrome. Tandem Mass Tags (TMT) multiplexin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2020-03-09 | PXD015307 | Pride
Tmt Cysteine sulfhydration 
ProteomicsNovel Mechanism and Therapy of Anthracycline-Induced Cardiotoxicity (AIC)
Anthracyclines are potent chemotherapeutic agents known for their efficacy in treating various cancers via inhibition of topoisomerase II alpha (TOP2A). However, their clinical use is limited due to cardiotoxicity, primarily attributed to off-target inhibition of topoisomerase II beta (TOP2B) in car...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD077277 | Pride
Top2b Smyd1 
TranscriptomicsRTN1 IS A NOVEL MEDIATOR FOR PROGRESSION OF KIDNEY DISEASE
Gene expression profiling of kidneys from the murine model of HIV-associated nephropathy (HIVAN) identified an association between the expression of an endoplasmic reticulum (ER)-associated protein reticulon-1, RTN1, and the severity of kidney disease. Of the three known RTN1 isoforms, only RTN1A pr...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-69074 | biostudies-arrayexpress
UnknownInternational Epidemiology of Carbapenemase-Producing Escherichia coli.
Not available
S-EPMC10444003 | biostudies-literature
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