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MetabolomicsIntegrated microbiome-metabolome-genome axis data of Laiwu and Lulai pigs
Excessive fat deposition can trigger metabolic diseases, and it is crucial to identify factors that can break the link between fat deposition and metabolic diseases. Healthy obese Laiwu pigs (LW) are high in fat content but resistant to metabolic diseases. In this study, we compared the fecal microb...
2023-04-20 | MTBLS3977 | MetaboLights
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
UnknownIntermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study.
Not available
S-EPMC8143028 | biostudies-literature
UnknownComprehensive analysis of the type VI secretion system in Neisseria: identification, distribution, and evolutionary insights.
Not available
S-EPMC12046857 | biostudies-literature
TranscriptomicsRoles of RDR701 and DCLs in Rice PhasiRNA biogenesis
In this study, we analyzed function of the rice RDR701 and various DCLs proteins in small RNA processing. small RNA deep sequencing analyses revealed that RDR701 and OsDCL4 is involved in tasiRNAs and 21- and 24-nt phasiRNAs biogenesis. Further analyses indicate RDR701 coupling with OsDCL4 and OsDCL...
ORGANISM(S): Oryza sativa 
2012-07-02 | E-GEOD-26405 | biostudies-arrayexpress
ProteomicsATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.
This dataset contains label-free immunoprecipitation mass spectrometry (IP-MS) data to identify interacting partners of target proteins in human cell lines. Two sample groups (OMM2.3-input, OMM2.3-IP) were generated via co-immunoprecipitation with anti-HBO1 antibody. All LC-MS/MS proteomic detection...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD081136 | Pride
Atr Histone acetyltransferase Phosphorylation Hbo1 Replication stress 
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
ProteomicsMTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
MTCH2 is a protein localized in the outer membrane of mitochondria. It belongs to the solute carrier 25 family, but its substrates or transporter function remains unknown. Previous research links MTCH2 to apoptosis induction, and Alzheimer’s disease, mitochondrial metabolism and dynamics, and MTCH2 ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-20 | PXD054881 | Pride
Mouse Brown adipocytes Dia 
TranscriptomicsSlr0643, a S2P Homolog, Is Essential for Acid Acclimation in Cyanobacterium Synechocystis sp. PCC 6803
Every cyanobacterial species contains gene encoding site-2-protease (S2P) homolog. The studied prokaryotic S2P homologs play essential roles in regulating stress response through intramembrane proteolysis of membrane-bound anti-sigma factors. Here, gene of Slr0643, one of four S2P homologs in Synech...
ORGANISM(S): Synechocystis sp. PCC 6803 
2012-09-18 | E-GEOD-37747 | biostudies-arrayexpress
ProteomicsRHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
To further investigate which molecules interact with RHOF in AML，we performed a comparative proteomic analysis of 293T cells overexpressing RHOF and control cells using liquid chromatography‒mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-09 | PXD052126 |
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