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ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
ProteomicsCo-immunoprecipitation of G-quadruplex-containing Core Promoter and nanoLC-FAMIS-MS/MS
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines, and they are distributed widely across the genome. G4 participates in multiple biological processes including gene transcription, and G4-targeted ligands serve as potential therapeutic age...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026830 | Pride
Human Core promoter Co-immunoprecipitation G-quadruplex Nuclear protein Nanolc-famis-ms/ms 
Proteomicsquantitative proteomic analysis of phagocytes in oyster Crassostrea gigas
Invertebrates lack the adaptive immune system homologous to that of vertebrates, thus depend exceptionally on the innate immune system for the pathogen recognition and clearance. Phagocytes play a pivotal role in the innate immunity of invertebrates, but the molecular basis underlying their phagocyt...
ORGANISM(S): Crassostrea Gigas 
2018-05-29 | PXD009987 |
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