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GenomicsThe complete methylome of hematopoietic stem cells and their immediate progeny
Hematopoietic stem cells (HSCs) constitute a rare cell population in bone-marrow and are capable of live-long self-renewal and production of all mature blood cell types. Cell differentiation processes are governed by epigenetic mechanisms whose study during early differentiation steps will provide i...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-52709 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide Regulation of Splicing and mRNA Localization by Muscleblind Proteins
The Muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in Myotonic Dystrophy (DM), where expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We identified transcriptome-wide functional and biophysical targets of Mbnl proteins i...
ORGANISM(S): Drosophila melanogaster 
2012-08-17 | E-GEOD-39911 | biostudies-arrayexpress
UnknownRole of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004.
Not available
S-EPMC4412629 | biostudies-literature
TranscriptomicsTrivalent arsenic inhibits the functions of chaperonin complex
The goal of this study was to identify yeast mutants with arsenite hypersensitivity. Keywords: dose response Matched pools of yeast knockout (YKO) mutants were grown in paired growth media lacking or containing arsenite at various concentrations. The relative abundances of the YKO mutants were profi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-26 | E-GEOD-5973 | biostudies-arrayexpress
TranscriptomicsMiSeq 2x300 paired-end sequencing of HEK293T cells stably expressing eGFP-PPP2R5A transduced with a HIV-1 Vif mutant library
The goal of this experiment was to map the binding surface between the HIV-1 Vif protein and the cellular phospho-regulator PPP2R5A. Previous studies had shown that Vif can target PPP2R5A for proteasomal degradation but the binding surface required had yet to be elucidated. For this experiment, HEK2...
ORGANISM(S): Homo sapiens 
2019-10-01 | E-MTAB-8357 | biostudies-arrayexpress
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
TranscriptomicsA novel post-translational mechanism controlling the oncogenic activity of c-Myc is enhanced in poor outcome breast cancer
Examination of Pin1-regulated Myc target genes in a human breast epithelial cell line. Two samples: control GFP-expressing MCF10A-Myc cells and Pin1-expressing MCF10A-Myc cells.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-33776 | biostudies-arrayexpress
TranscriptomicsHigh-throughput pyrosequencing of plant virus small RNAs
Plant virus infection involves the production of viral small RNAs (vsRNAs) with the potential to associate with distinct Argonaute (AGO)-containing silencing complexes and mediate diverse silencing effects on RNA and chromatin. We used multiplexed, high-throughput pyrosequencing to profile populatio...
ORGANISM(S): Melon necrotic spot virus 
2009-07-09 | E-GEOD-16996 | biostudies-arrayexpress
GenomicsInternational Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN)

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

phs000216.v1.p1 | EGA
TranscriptomicsNormal Lung + Lung adenocarcinoma microarray
Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be eit...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-231 | biostudies-arrayexpress
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