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TranscriptomicsPost-transcriptional regulation of circadian rhythm by miRNA in mouse liver
Gene regulatory circuit of circadian rhythm has been well studied at the transcriptional level. However, recent published Nascent-sequencing and proteomic data indicates that post-transcriptional mechanisms play essential roles in modulating temporal gene expression for proper circadian function. mi...
ORGANISM(S): Mus musculus 
2015-06-30 | E-GEOD-59423 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by Illumina sequencing technology
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
2010-11-30 | E-GEOD-19807 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Gata3 [ChIP-seq and RNA-seq]
Shh and its receptor Ptch1 define two adjacent mutually exclusive domains: Shh+Ptch1- and Shh-Ptch1+ of E11.5 mouse brain. Gata3 ChIP-seq experiments and RNA-seq assays on Gata3-knockdown cells revealed that Gata3 up-regulates genes enriched in Shh-Ptch1+ domain. Our work is the first genome-wide ch...
ORGANISM(S): Rattus norvegicus 
2013-11-30 | E-MTAB-2008 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling by Agilent mouse miRNA microarray
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
2010-11-30 | E-GEOD-19427 | biostudies-arrayexpress
TranscriptomicsNew targets of TEAD1 revealed by ChIP-on-chip
TEAD1 acts as a key molecule of muscle development, and trans-activates multiple target genes involved in cell proliferation and differentiation pathways. However, its target genes in skeletal muscles, regulatory mechanisms and networks are unknown. Here, we use ChIP-on-chip to identify direct targe...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26107 | biostudies-arrayexpress
MetabolomicsFecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus
The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patien...
2020-01-30 | MTBLS916 | MetaboLights
ProteomicsEstablishment of a new isolation method for urinary exosomes
We developed a urinary exosome isolation kit (EVLatch), which enables enrichment of exosomes from human urine with higher purity and yield than ultracentrifugation
ORGANISM(S): Homo Sapiens 
2024-03-14 | PXD050607 |
TranscriptomicsModulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)
We analyzed gene expression in the American black bear, Ursus americanus, using a custom 12,800 cDNA probe (BA02) microarray to detect differences in expression that occur in heart and liver during winter hibernation in comparison to summer active animals. We identified 245 genes in heart and 319 ge...
ORGANISM(S): Ursus americanus 
2011-05-10 | E-GEOD-27875 | biostudies-arrayexpress
TranscriptomicsCircadian clock drives novel functions through transcriptional cascade
Using larval zebrafish as a model system, we applied a genome-wide transcriptome approach that allowed us to investigate circadian gene expression that can be associated with various tissues and cell types. Our analysis of circadian gene regulatory network revealed a general principle: circadian clo...
ORGANISM(S): Danio rerio 
2012-04-25 | E-GEOD-37332 | biostudies-arrayexpress
ProteomicsCholesterol modulates the physiological response of nanoparticles by governing protein corona
Metabolome profile is an unexploited factor impacting the target efficacy and safety of nanomedicines by manipulating the formation of protein corona, and provide a novel way to develop personalized nanomedicines by harnessing disease-related metabolites.
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus 
2023-03-24 | PXD041073 |
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