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ProteomicsTarget of Dleu2-17aa in CD4+ T cells
To identify Dleu2-17aa micropeptide interacting proteins in CD4+ T cells, we performed pull-down assays fllowed by LC-MS using biotin-labeled Dleu2-17aa. As controls, we included the unlabeled free Dleu2-17aa and a biotin-only group. Pull-downs were carried out in both primary mouse CD4+ T cells and...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-23 | PXD046468 | Pride
Cd4+ t cells Micropeptide 
ProteomicsPP6 interated proteins in HaCaT cells treated with L-menthol
Because HES1 maintained PP6 protein level without affecting its mRNA level, we asked if HES1 directly interacted with PP6 in keratinocytes.
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037336 | Pride
Igbp1 Pp6 Hacat L-menthol 
ProteomicsTarget of L-menthol in keratinocytes
To elucidate the PP6-upregulation mechanism of L-menthol, we took advantage of an unbiased target identification approach, DARTS, to identify the target of L-menthol in keratinocytes.
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037335 | Pride
Keratinocyte，hes1 L-menthol 
TranscriptomicsEpigenetic silencing of SFRP4 contributes to epidermal hyperplasia in psoriasis
To investigate the gene expression of imiquimod induced psoriasis-like mouse model, we have employed whole genome microarray as a discovery platform to identify genes differentially expressed compared with wild type C57BL6 mouse exposed to the vehicle of imiquimod. C57BL/6J mice at 6 to 8 weeks of ...
ORGANISM(S): Mus musculus 
2014-08-28 | E-GEOD-60804 | biostudies-arrayexpress
TranscriptomicsGene expression profiling for 2 cell samples
Mesenchymal stem cells (MSCs) exhibit immunosuppressive properties. However the homing mechanisms underlying MSC trafficking to target tissues remain elusive. Here we report that skin-derived MSCs (S-MSCs) secrete high levels of interleukin-6 (IL-6), inhibit T helper (Th)1- and Th17-cell differentia...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42914 | biostudies-arrayexpress
TranscriptomicsComparative miRNA expression of normal skin from control and lesional skin from mice
The efficacy of monoclonal antibodies against either interleukin (IL)-17 or the IL-17 receptor in psoriasis therapy provides strong evidence that IL-17 is the major inflammatory mediation in this disease. However, how IL-17 induces epidermal hyperplasia in psoriasis remains largely unknown. Here, we...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50099 | biostudies-arrayexpress
ProteomicsMetabolic characterization of hepatic disease patients with hepatitis B virus DNA replication by untargeted metabolomics
Purpose: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive hepatic diseases (hepatitis, cirrhosis or liver cancer). Still, the metabolic processes operational during the distinct clinical phases of a chro...
ORGANISM(S): Homo Sapiens 
2021-05-13 | PXD025989 |
UnknownAssociation between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
Not available
S-EPMC2685754 | biostudies-literature
ProteomicsProteomic IP-MS analysis of Asprosin/PFKP in regulating cardiac hypertrophy model
This dataset contains two parts of proteomics data: a) the identification and analysis results of co-immunoprecipitation (Co-IP: Flag-asprosin/HA-PFKP) in cardiomyocytes overexpressing Flag-asprosin/HA-PFKP; b) the identification and analysis results of co-immunoprecipitation (Co-IP) using IgG as a ...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072385 |
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