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ProteomicsProteomic analysis of extracellular vesicles from inflammatory fibroblasts in colorectal cancer lung metastasis
Pulmonary metastasis is a major cause of mortality in colorectal cancer (CRC), and the tumor microenvironment plays a critical role in metastatic progression. In particular, inflammatory fibroblasts have been implicated in shaping the metastatic niche; however, the molecular characteristics of their...
ORGANISM(S): Homo Sapiens 
2026-03-20 | PXD075933 |
ProteomicsProteomics analysis for liver from WT and Hsd17b6 liver specific knockout mice
Eight weeks old LSL-Cas9 mice were injected with AAV2/8 expressing Cre driving by TBG promoter and sgRNA of gene of interest to specifically knockout gene in liver. In the present study, either control or sgHsd17b6 virus are injected. The mice are subjected to high fat choline dificient diet feeding...
ORGANISM(S): Mus Musculus 
2024-10-02 | PXD056581 |
ProteomicsTranscriptome and proteome of ovarian revealed the differences in the ovaries of dairy goats during the breeding and non-breeding seasons
dairy goats represent a crucial species within global dairy livestock. In temperate regions with distinct seasons, dairy goats exhibit reduced reproductive activity under long photoperiod conditions—a phase termed the non-breeding season. This poses a significant challenge to sustaining year-roun...
ORGANISM(S): Capra Hircus 
2025-06-24 | PXD065416 |
ProteomicsHematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery
To investigate the cellular and molecular mechanisms underlying the specific targeting of HSPC-Lipo nanoparticles to the bone marrow of leukemic mice, we performed mass spectrometry to map the proteomics of HSPC-Lipo nanoparticles and HSPC cell membrane.
ORGANISM(S): Mus Musculus 
2024-06-06 | PXD052979 |
TranscriptomicsSingle-cell RNAseq of Human T lymphocyte derived from H7N9 infected patients
Comparing transcriptomes of CD8 T cells derived from a fatal H7N9 influenza infection with those derived from a patient that survived the infection. Specifically, CD38+ HLA-DR+ cells were sorted by flow cytometry at different sampling time-points, and the transcriptome was analysed using Smart-seq2.
ORGANISM(S): Homo sapiens 
2018-01-30 | E-MTAB-6379 | biostudies-arrayexpress
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
ProteomicsProteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto's Thyroiditis
To understand Hashimoto's Thyroiditis and translate this knowledge to clinical applications, we took mass spectrometric analysis on thyroid tissue fine-needle puncture from HT patients and healthy people in an attempt to make a further understanding of the pathogenesis of Hashimoto's Thyroiditis.
ORGANISM(S): Homo Sapiens 
2021-09-10 | PXD028448 |
ProteomicsComprehensive mass spectral libraries of human thyroid tissue and cells
We established deep-coverage thyroid-specific spectral libraries encompassing over 12,000 proteins, including samples from nine types of thyroid primary and lymph node metastases tissues and fifty thyroid cancer cell lines.
ORGANISM(S): Homo Sapiens 
2024-09-27 | PXD051051 |
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