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ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To identify which E3 ligases ubiquitinate PD-L1, we overexpressed PD-L1-Flag in HEK293 cells and used anti-Flag magnetic beads to pull down PD-L1 from cell lysates. The interacting proteins were then analyzed by mass spectrometry, revealing that three E3 ligases interact with PD-L1.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057691 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsMFGE8 induces anti-PD-1-therapy resistance by promoting extracellular vesicle sorting of PD-L1
To elucidate which secreted factors in tumor tissues (TTs) are responsible for the upregulation of UBE4A as the tumor progresses, we inoculated tumors in mice and analyzed the 2- and 4-week TT fluid by mass spectrometry (MS). By combining molecular weight cut off(MWCO) and the identification of secr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058079 | Pride
Anti-pd-1-therapy resistance Ube4a Extracellular vesicles Mfge8 Pd-l1 
ProteomicsRSDR, a Novel Potential Biomarker, Protects Against AKI by Interacting with hnRNPK to Regulate DHODH-Mediated Ferroptosis
Molecular analyses—including RNA immunoprecipitation, pull-down assays, mass spectrometry, and chromatin immunoprecipitation sequencing—demonstrated that RSDR and hnRNPK stabilize each other, forming a positive feedback loop that amplifies DHODH expression.
ORGANISM(S): Mus Musculus 
2025-03-19 | PXD062047 |
ProteomicsComprehensive analyses of the macrophages infected with avirulent and virulent Mycobacterium tuberculosis strains uncover distinct immune mechanisms and anti-TB effect of treated exosomes
Protein data of exosomes from Mycobacterium tuberculosis-infected macrophages
ORGANISM(S): Homo Sapiens 
PXD078478 |
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