Sort   by:  
 Page size 
ProteomicsLong noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly
Long non-coding RNAs (lncRNAs) are family of gene regulators but the functional study of lncRNAs in skeletal muscle satellite cells (SCs) remains at the infancy stage. Here we identify SAM (Sugt1 associated muscle) lncRNA (also known as Snhg15, (small nucleolar RNA host gene 15) that is enriched in ...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-18 | PXD018147 | Pride
Lc-ms 
ProteomicsThe SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands
CpG-islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 possesses an atypical winged-he...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD016781 | Pride
Chromatin Transcription Cpg islands 
UnknownStructural basis for tRNA methylthiolation by the radical SAM enzyme MiaB.
Not available
S-EPMC9107155 | biostudies-literature
UnknownSpectroscopic characterization and mechanistic investigation of P-methyl transfer by a radical SAM enzyme from the marine bacterium Shewanella denitrificans OS217.
Not available
S-EPMC4362910 | biostudies-literature
TranscriptomicsEssential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency
Here we delineate the roles of RNA binding for WDR5 function on chromatin state and murine embryonic stem cell (ESC) maintenance. Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points during the transdifferentiation process
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53035 | biostudies-arrayexpress
TranscriptomicsMBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain
For some neurological disorders, disease is primarily RNA-mediated due to expression of non-coding microsatellite expansion RNAs (RNAexp). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their normal cellular targets. However, experimental evide...
ORGANISM(S): Mus musculus 
2015-07-30 | E-GEOD-68890 | biostudies-arrayexpress
UnknownMulti-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain.
Not available
S-EPMC10723468 | biostudies-literature
TranscriptomicsContext-dependent actions of Exendin-4 on β-cell function and dynamic changes in islet gene expression over time in vivo
GLP-1 analogues, such as exendin-4, preserve functional β-cell mass in various model systems and are revolutionising management of type 2 diabetes. Yet, comparatively little is known about effectiveness in the face of severe β-cell depletion. Moreover, direct and sequential effects of exendin-4 on...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-37936 | biostudies-arrayexpress
UnknownHyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.
Not available
S-EPMC11755893 | biostudies-literature
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
Sort   by:  
 Page size