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UnknownOmics-based profiling and therapeutic potential of natural components in pan-Shennongjia medicinal herbs.
Not available
S-EPMC12529840 | biostudies-literature
TranscriptomicsTranscription profiling by array of human wild type and gefitinib-resistant A431 cancer cells
A431 wild-type (wt) cancer cell line is sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs). By culturing it chronically under gefitinib, it eventually becomes resistant (A431_GR cell). We know of a few proteins involved in this mechanism of drug resistance, but a cDNA exprssion array...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10696 | biostudies-arrayexpress
ProteomicsEffect of cryopreservation of lysate/tissue on EOC tissue-derived EVs
We optimized a method previously developed to extract EVs from epithelial ovarian cancer (EOC) tissues and investigated whether cryopreservation of EOC tissues in clinical practice affects the phenotypes, contents, and biological functions of subsequently extracted EVs.
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039422 | Pride
Human Ovarian cancer Extracellular vesicles Lc-ms/ms 
ProteomicsProteomics of 58 platinum-sensitive and 30 platinum-resistant ovarian cancer tissue-derived exosomes
In this study, 4D data-independent acquisition (DIA) proteomic sequencing was performed on exosomes obtained from 58 platinum-sensitive and 30 platinum-resistant patients with EOC. The analysis revealed a notable enrichment of differentially expressed proteins that were predominantly associated with...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051500 | Pride
Human Ovarian cancer Tissue-derived exosomes 4d dia proteomics 
UnknownArtemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment.
Not available
S-EPMC12853929 | biostudies-literature
TranscriptomicsInvestigation of gene expression signature induced by Alk5TD (active type I TGF-beta receptor)
BT474 cells stably expressing Alk5TD or vector (BT474-Alk5TD and BT474-pBMN, respectively) were compared for gene expression. Genes that were differentially expressed between the two cell lines were collected as the signature induced by Alk5TD expression. Keywords: Comparison of two cell types (BT47...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-11293 | biostudies-arrayexpress
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
UnknownMicrobiota-derived tryptophan metabolism and AMPK/mTOR pathway mediate antidepressant-like effect of Shugan Hewei Decoction.
Not available
S-EPMC11439769 | biostudies-literature
TranscriptomicsDe novo sequencing of circulating microRNAs in locally advanced breast cancer
MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling of circulating small RNAs has not been previously reported in breast cancer (BC), and was carried out in this study to identify blood-based sm...
ORGANISM(S): Homo sapiens 
2013-07-20 | E-GEOD-49035 | biostudies-arrayexpress
UnknownTangeretin Suppresses LUAD via SSTR4 Downregulation: Integrated Bioinformatics and Functional Validation.
Not available
S-EPMC12842074 | biostudies-literature
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