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Neural progenitor cells (NPCs) can be induced from somatic cells by defined factors. Here we report that NPCs can be generated from mouse embryonic fibroblasts by a chemical cocktail, namely VCR (V, VPA, an inhibitor of HDACs; C, CHIR99021, an inhibitor of GSK-3 kinases and R, Repsox, an inhibitor o...
ORGANISM(S): Mus musculus 
Despite recent advances, rheumatoid arthritis (RA) patients remain refractory to therapy. Dysregulated overproduction of angiopoietin-like 4 protein (ANGPTL4) is thought to be contributed to the disease development. Therefore, interference with ANGPTL4 biological function may constitute a new therap...
ORGANISM(S): Rattus Norvegicus 
Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive techno...
ORGANISM(S): Mus Musculus 
2022-11-23 | PXD038293 |
Mouse bone marrow macrophages, with or without the addition of RANKL, are being investigated for their interactions with proteins that associate with the stomatin protein.
ORGANISM(S): Mus Musculus 
2025-03-13 | PXD061779 |
Neuronal conversion from human fibroblasts can be induced by lineage-specific transcription factors, holding great promise for human neurological disease modeling and regenerative medicine. However, the introduction of ectopic genes limits their therapeutic applications. Here, we report that neurona...
ORGANISM(S): Homo sapiens 
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