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ProteomicsProteomics analysis of blood neutrophils from WT and Wnt5 DKO mice under DSS treatment
Neutrophils are abundant innate immune cells with important roles in host defense and many inflammatory diseases. They possess plasticity and heterogenicity, which underlie their functional ambivalency; they can be beneficial or detrimental to host well-being depending on contexts. While bone marrow...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD048613 | Pride
Wnt5 Neutrophil Proteomics Dia 
ProteomicsProteomic analysis of the physiological E3 ubiquitin ligase responsible for PIN1 degradation
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD046325 | Pride
Pin1 Proteomics Cdh1 
ProteomicsProteomics analysis of expi293 conditioned media purified with immobilized metal affinity chromatography
Isthmin-1 (ISM1) is a recently described adipokine with insulin-like properties, reported to regulate hyperglycemia and liver steatosis. However, contrary to earlier studies, we demonstrate that highly purified ISM1 does not stimulate AKT phosphorylation in 3T3-F442A pre-adipocytes. Instead, this ac...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD062353 | Pride
Dia Proteomics Akt 
ProteomicsProteomic and phosphoproteomic profilings in fibroblasts of 11 common mammalian species
A central goal of modern biology is to understand the molecular basis of phenotype evolution between species. Previously, the evolutionary profiling at the molecular level has been largely limited to the nucleotide level. Nevertheless, the genotype is translated to proteotype through comprehensive a...
ORGANISM(S): Bos taurus (Bovine) Sus scrofa (Pig) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) Canis lupus Monodelphis domestica Felis catus (Cat) (Felis silvestris catus) Rattus norvegicus (Rat) Ovis aries Macaca mulatta (Rhesus macaque) Equus caballus (Horse) 
2022-09-22 | PXD028979 | Pride
Phosphoproteomics Dia-ms Multiple species Quantitative proteomics 
ProteomicsPhosphoproteomic analysis supporting structural basis for GABAA receptor pi activation
GABAA receptors (GABAAR) are pentameric chloride channels comprising various combinations of different subunits that are activated by γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in vertebrates. we show here that GABRP chloride channel activity and ERK signaling is directly regul...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD044482 | Pride
Phosphoproteomics Dia Gabaa receptor 
ProteomicsBioactive components of Mongolian medicinal Gentiana dahurica Fisch. flowers inhibit the NF-κB signaling pathway and ameliorate chronic obstructive pulmonary disease
Bioactive components of Mongolian medicinal Gentiana dahurica Fisch. flowers inhibit the NF-κB signaling pathway and ameliorate chronic obstructive pulmonary disease
ORGANISM(S): Mus Musculus 
2026-04-08 | PXD076741 |
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