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Increasing evidence suggests that diverse RNA binding proteins interact with regulatory RNAs to regulate transcription. RBFox2 is a ubiquitous RNA binding protein with prevalent expression in stem cells, heart, and brain. Here, we report a systematic dissection of the RBFox2-regulated RNA program in...
ORGANISM(S): Mus musculus 

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

Ranaviruses are promiscuous pathogens that can infect across species barriers in aquatic animals. Here, a complicated replication and transcription machinery were screened and uncovered from the two ranavirus infected lower vertebrate cells by isolation of proteins on nascent DNA, recombinant virus-...
ORGANISM(S): Rana Grylio Virus 9506 Andrias Davidianus Ranavirus Andrias Davidianus 
2021-02-07 | PXD024049 |
Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic...
ORGANISM(S): Caenorhabditis Elegans 
2021-06-10 | PXD020440 |
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