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Isobaric chemical tag labeling (e.g., iTRAQ and TMT) is a commonly used approach in quantitative proteomics research. Typically, peptides are covalently labeled with isobaric chemical tags, and quantification is enabled through detection of low-mass reporter ions generated after MS2 fragmentation. R...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD037491 | Pride
Based on the TurboID proximity labeling technology, the interacting proteins of FOXO1 were studied and divided into three groups: blank group U251 cells, FOXO1-U251 overexpressing cells, and FOXO1-U251 cells treated with LPS. The three groups of cells were affinity purified by streptomycin magnetic ...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036171 |
In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.
ORGANISM(S): Mus Musculus 
2024-03-20 | PXD050789 |
Our findings suggest that DIA combined with PRM mass spectrometric method was effective in identifying and validating the candidate biomarkers for several diseases including EGPA diagnosis. We have discovered and validated three new potentially serum biomarkers FGA, SAP and CETP for discriminating E...
ORGANISM(S): Homo Sapiens 
2022-02-15 | PXD029759 |
We performed proteomics analysis on Lmna-/- hearts from mice at 2 weeks and 1 month of age to investigate the underlying mechanism by which LMNA deletion evokes DCM
ORGANISM(S): Mus Musculus 
2023-06-25 | PXD043270 |
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