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ProteomicsTMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis
In the present study, we detected the alterations of the CSF protein spectrum of CVST patients by TMT technique, screen differentially expressed proteins, analyze the functions of these signals through bioinformatics methods, and finally validate the key molecules through parallel reaction monitorin...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD038259 |
ProteomicsProteomic stratification of prognosis and treatment options for small cell lung cancer
We analyzed surgically resected formalin-fixed, paraffin-embedded (FFPE) SCLC samples by proteomic profiling and stratified SCLC into three subtypes (S-I, S-II, and S-III) with distinct clinical outcomes and chemotherapy responses.
ORGANISM(S): Homo Sapiens 
PXD064316 |
ProteomicsDefective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia
Preeclampsia(PE)is a severe placental disorder that affects 3%-5% of all pregnancies worldwide. The primary cause of PE is abnormal placentationduring eanly pregnancy, including poor trophoblast invasion and insutficientapiral arteriole remodeling, Protein O-ucosylation is a type of protein posttran...
ORGANISM(S): Homo Sapiens 
2025-12-25 | PXD072416 |
ProteomicsHIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos
In order to understand the molecular mechanism underlying the action of dPCIF1 in early embryos, we carried out co-immunoprecipitation (co-IP) assays followed by mass spectroscopic analysis using dPCIF1GFP-KI early embryos (0.5–1.5 hours). In this assay, we identified a large number of dPCIF1-intera...
ORGANISM(S): Drosophila Melanogaster 
2024-01-18 | PXD048659 |
ProteomicsIntegrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention
The label-free methods of proteomic combined with metabolomics were applied to explore the mechanisms of Cryptotanshinone intervention in rats with acne. These results propose action mechanisms for the use of CPT in acne, as a safe and potential new drug.
ORGANISM(S): Rattus Rattus 
2021-07-12 | PXD027219 |
ProteomicsProteomic analysis of Hypsibius henanensis sp.nov. suffered from 12C6+ heavy ion radiation based on label-free technology
Tardigrades are a kind of species that can tolerate ultra-high doses of ionizing radiation. Here, we used heavy ions at different doses of 0,200 and 2000Gy to irradiate Hypsibius henanensis sp.nov.. Label-free proteomic identification was performed on the samples, each dose containing 3 repetitions
ORGANISM(S): Tardigrada 
PXD045537 |
ProteomicsDetection of betalains from the extracts of H. henanensis sp. nov.
Identification of betalains from the extracts of H. henanensis sp. nov. using untargeted metabolomics.
ORGANISM(S): Tardigrada 
2024-03-22 | PXD050882 |
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