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ProteomicsProximity Proteomics Revealed Dicer1 and Transporters as Client Proteins of Aha1
Co-chaperone Aha1 activates HSP90 ATPase to promote the folding of client proteins. However, the client proteins of Aha1 are largely unknown. By employing ascorbate peroxidase (APEX) based proximity labeling, we identified 32 proximity proteins of HSP90 that are modulated by genetic depletion of Aha...
ORGANISM(S): Pan troglodytes (Chimpanzee) Homo sapiens (Human) 
2022-11-19 | PXD028980 | Pride
Hsp90 Dicer1 Apex Proximity labeling Aha1 
ProteomicsThe host targets of SARS-CoV-2 protein NSP5
To identity the host targets of the SARS-CoV-2 protease NSP5, SILAC-based quantitative proteomics was performed in comparing the binding partners of wildtype or catalytically-inactive C145A mutant.
ORGANISM(S): Homo sapiens (Human) 
2021-10-27 | PXD023277 | Pride
Silac Sars-cov-2 Nsp5 Proximity labeling 
ProteomicsThe proximal proteome of 17 SARS-CoV-2 proteins links to disrupted host antiviral signaling and translation
To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics.
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023239 | Pride
Sars-cov-2 Proximity labeling Bioid 
ProteomicsGlucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD028561 | Pride
Proximity labeling Ddx21 Splicing Glucose Bioid Epidermal differentiation 
UnknownDesign and Multicenter Clinical Validation of a 3-Dimensionally Printed Nasopharyngeal Swab for SARS-CoV-2 Testing.
Not available
S-EPMC7893548 | biostudies-literature
UnknownLow-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.
Not available
S-EPMC8802633 | biostudies-literature
UnknownThe utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial.
Not available
S-EPMC3271983 | biostudies-literature
Genomicsena-DATASET-GoT2D/T2D-GENES-09-07-2016-02:03:47:226-1135 - samples
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
EGAD00001002247 | EGA
GenomicsImputation analysis file
This data set includes the following summary level data file used for the imputation data: imputation.sv.assoc.txt: results from single variant association analysis in imputed samples
EGAD00010001184 | EGA
Genomics13K T2D-GENES analysis files
This data set includes the following summary level data files used for the 13k analysis of T2D-GENES data: wes.variants.list: list of variants to keep for any analysis of the exomes data wes.assoc.samples.list: list of samples to keep for association analysis wes.assoc.variants.list: list of variant...
EGAD00010001188 | EGA
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