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ProteomicsHuman LC-MS, TMEM216 inhibits breast cancer lung metastasis by modulating IGF1R-IRS4 signaling pathway
Immunopurification and mass spectrometry analysis of TMEM216-associated proteins. Cellular extracts from Flag-TMEM216-expressing 293FT cells were affinity-purified. The eluates were resolved by SDS-PAGE and stained with Coomassie Brilliant Blue. The protein bands were retrieved and analyzed by mass ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD061739 | Pride
Human 293ft cells 
ProteomicsBLM-G4 pulldown IP-MS in human colon cancer HT-29 cells
the experiment uses biotin-labelled BLM-G4 to incubate with HT-29 cell lysates, and uses streptavidin agarose beads to pulldown BLM-G4-binding proteins. Utilize LC-MS/MS to annotate and quantify the proteins pulled down by BLM-G4.
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075345 | Pride
Pulldown Blm-g4 Ip-ms Ht-29 cell 
UnknownGSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions.
Not available
S-EPMC6251088 | biostudies-literature
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
UnknownCurcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites.
Not available
S-EPMC11395590 | biostudies-literature
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
ProteomicsA proteomic view of WT and △ydiV(stm1344) Salmonella Typhimurium in simulated host environment medium
The flagellum provides essential motility in the pathogenic process of Salmonella host invasion. However, flagellin is strongly antigenic and can be recognized by TLR5, resulting in activation of the host immune system to clear the invading pathogen. The presence of flagella also disrupts the integr...
ORGANISM(S): Escherichia coli 
2022-10-12 | PXD035693 | Pride
Differential protein expression  simulated host environment medium  wt and △ydiv 
Genomicsena-DATASET-BGI-18-06-2015-05:57:10:511-19 - samples
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
EGAD00001001398 | EGA
Genomicsena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples
We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.
EGAD00001001397 | EGA
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