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ProteomicsBeclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057003 | Pride
Beclin 1 Mouse Fetal liver 
ProteomicsProteomic analysis of Ganoderma sessile biotransformation of 15,16-dihydrotanshinone Ⅰ to obtain ganoderic acid
Biotransformation of 15,16-dihydrotanshinone Ⅰto shaker-cultured Ganoderma sessile mycelium to produce ganoderic acid, proteomic analysis of biotransformed mycelium and normal G. lsessile mycelium
ORGANISM(S): Ganoderma Sessile 
2023-03-07 | PXD040674 |
ProteomicsBiomarker Prediction for Lung Cancer Chemoradiotherapy Efficacy Based on Proteomics
The response of lung cancer to chemoradiotherapy (CRT) is orchestrated by the dynamic interplay between immune microenvironment remodeling and metabolic reprogramming. However, robust biomarkers for predicting patient prognosis remain elusive. In this study, we performed proteomics profiling of 22 p...
ORGANISM(S): Homo Sapiens 
2026-03-19 | PXD075840 |
ProteomicsDeacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that different proteins and their acetylation modification r...
ORGANISM(S): Homo Sapiens 
2023-02-20 | PXD040298 |
ProteomicsIdentification of the indisulam-regulated proteins in AGS cells using label-free quantitative proteomics
In this project, we used label-free quantitative proteomics to identify proteins that are differentially regulated by indisulam in the gastric cancer AGS cell line.
ORGANISM(S): Homo Sapiens 
2024-10-09 | PXD056709 |
ProteomicsPorphyromonas gingivalis infection and atherosclerosis
To explore the effect of Porphyromonas gingivalis on lipid-laden macrophages, the project was conduct. Overall design: 8 samples, 4 replicates in 2 groups, with ox-LDL-treated RAW264.7 macrophages stimulated with or without Porphyromonas gingivalis.
ORGANISM(S): Mus Musculus 
2024-01-09 | PXD048371 |
ProteomicsAnnexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
Annexin A2 causes motor incoordination via muscle-cerebellum axis in sarcopenia
ORGANISM(S): Mus Musculus 
2025-09-22 | PXD068704 |
ProteomicsEasySCP Unveils Extensive Liver Zonation at Single-cell Proteomics Resolution
The widespread adoption of single-cell proteomics (SCP) in biology has been limited by complex workflows and reliance on specialized instrumentation. Here we present EasySCP, a high-throughput and lossless method that integrates FACS-based single-cell sorting, an all-in-one, single-step digestion pr...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-10-30 | PXD070083 |
ProteomicsMass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation
S-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in ...
ORGANISM(S): Mus Musculus 
2024-03-12 | PXD050569 |
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