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ProteomicsMass spectrometry data of human urine
Based on UPLC-Q-TOF-MS metabolomics technology, urine samples of 1072 subjects from 9 centers, including normal control, phlegm and blood stasis (PBS) syndrome and Qi and Yin deficiency (QYD) syndrome, and other syndromes of CHD, were conducted to find biomarkers. Among them, the discovery set (n = ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-27 | PXD012910 | Pride
Human Urine Uplc-q/tof-ms 
ProteomicsIdentification of Unknown Biological Toxin Protein Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin
Currently, the genomes of many toxin proteins remain unsequenced. Characterizing these toxin proteins and their active peptide segments is crucial for the development of detoxification agents and for discovering proteins with potential therapeutic applications. Existing methods for identifying and d...
ORGANISM(S): Ricinus communis 
2025-12-01 | PXD061213 | Pride
Unknown biological toxin protein Heuristic denovo protein sequencing Ricin toxin De novo sequencing Mass spectrometry 
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
ProteomicsProbing the Role of O-GlcNAcylation in Modulating Protein-DNA Interactions: Insights from a Proteomic Transcription Factor Response Element-Based Pulldown Screening Approach
O-linked β-N-acetylglucosamine (O-GlcNAc), a critical post-translational modification (PTM) predominantly found in the nucleus, plays a substantial role in regulating gene expression by modulating transcription factors (TFs) activity. Herein, by utilizing a pulldown screening approach termed as tand...
ORGANISM(S): Homo Sapiens 
2024-10-24 | PXD057128 |
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
ProteomicsO-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNA...
ORGANISM(S): Homo Sapiens 
2023-03-31 | PXD041284 |
ProteomicsChromatin-associated OGT promotes hepatocellular carcinoma malignancy via activating ZNF263
OGT, the only facilitator which attaches the monosaccharide to many oncogenic factors or tumor suppressors, has been suggested to play an influential role in tumorigenesis and metastasis of HCC. OGT interactome analyses indicates that disordered OGT may serve as a hub protein to activate the buildin...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039365 |
ProteomicsDefective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia
Preeclampsia(PE)is a severe placental disorder that affects 3%-5% of all pregnancies worldwide. The primary cause of PE is abnormal placentationduring eanly pregnancy, including poor trophoblast invasion and insutficientapiral arteriole remodeling, Protein O-ucosylation is a type of protein posttran...
ORGANISM(S): Homo Sapiens 
2025-12-25 | PXD072416 |
ProteomicsCleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
Metabolic heterogeneity resulting from the intrinsic heterogeneity of human tumors has been shown to cause a myriad of adverse outcomes of tumor therapy, including resistance to chemotherapy, but the mechanisms inside remain largely unknown. Here, we found that the de novo pyrimidine synthesis pathw...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059365 |
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