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ProteomicsEnhanced STEAP4 Ubiquitination in Obesity: Insights from Combined Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue
Obesity remains a worldwide health issue, with visceral adipose tissue as a leading driver of this pathology. As the executors of biological functions in living cells, proteins have their activity regulated by diverse post-translational modifications, including ubiquitination. However, obesity-relat...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-26 | PXD070339 | Pride
ProteomicsEnhanced STEAP4 ubiquitination in Obesity: Insights from Integrated Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue
We obtained the global proteomic and ubiquitylomic data of epididymal VAT from lean and obese male mice by mass spectrometry. Our proteomic analyses revealed significant changes of metabolic pathways involved in fatty acid, acyl-CoA and branched chain amino acids metabolism in obese VAT. Intriguingl...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-23 | PXD060435 | Pride
Ubiquitylome Obesity Steap4 Proteome 
UnknownRegulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
Not available
S-EPMC10291812 | biostudies-literature
MetabolomicsUntargeted Metabolomics of the enthesis interstitial fluid of wild-type and Nlrp3-/- mice with sham operation and injury post 7 days
In order to investigate the effect of the NLRP3 inflammasome on the regeneration of enthesis, we established an enthesis injury and repair model in wild-type and NLRP3-/- mice. The interstitial fluid of enthesis was extracted, and untargeted metabolomics was conducted to discover differential metabo...
2025-07-08 | MTBLS12150 | MetaboLights
ProteomicsIdentification of SNHG9-binding proteins in Huh7 cells using RNA pull-down assay
This project aims to identify the specific proteins interacting with lncRNA SNHG9 in hepatoma cells. We performed RNA pull-down assays using biotin-labeled SNHG9 probes in Huh7 cell lysates, followed by mass spectrometry (LC-MS/MS) to analyze the pulled-down protein.
ORGANISM(S): Homo Sapiens 
PXD077375 |
UnknownTreatment with Rhodiola crenulata root extract ameliorates insulin resistance in fructose-fed rats by modulating sarcolemmal and intracellular fatty acid translocase/CD36 redistribution in skeletal muscle.
Not available
S-EPMC4942897 | biostudies-literature
UnknownTotal Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Not available
S-EPMC4963894 | biostudies-literature
UnknownGut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids.
Not available
S-EPMC11539449 | biostudies-literature
ProteomicsA blood-based multi-omic landscape for the molecular characterization of Kidney Stone Disease
We adopted high-throughput sequencing and mass spectrometry (MS) techniques in this study and carried out an integrative analysis of exosome proteome and DNA methylation data from blood samples of normal and Kidney stone disease patients to screen biomarkers.
ORGANISM(S): Homo Sapiens 
PXD044503 |
ProteomicsTunable activated esters for lysine labeling in proteome
The development of various heteroaromatic activated esters designed for selective lysine labeling within the proteome for profiling purposes. Through systematic optimization of the reactivity and selectivity of these esters, we identified a series of effective probe molecules suitable for both in vi...
ORGANISM(S): Homo Sapiens 
PXD051323 |
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