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TranscriptomicsCell cycle dependence of neuroprogenitor fate determination regulated by Trrap-mediated histone acetylation
Epigenetic control of neural stem/progenitor cell fate is fundamental to achieve a fully brain architecture. Two intrinsic programs regulate neurogenesis, one by epigenetic-mediated gene transcription and another by cell cycle control. Whether and how these two are coordinated to determine temporall...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-43650 | biostudies-arrayexpress
ProteomicsTrrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity
The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-02 | PXD013730 | Pride
Trrap Neurodegeneration Lysine acetylation Sp transcription factors Wnt signalling 
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-05 | PXD013414 | Pride
Metabolism Atr Mitochondrial function 
ProteomicsRole of ATR in mitochondrial functions and metabolism
The PIKK superfamily member ATR is a key factor in DNA damage response (DDR) and is vital for the maintenance of genomic stability. DNA single strand breaks (SSBs) and replication stress activate ATR to phosphorylate a wide range of downstream substrates, which activates cell cycle checkpoint, senes...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD013469 | Pride
Metabolism Atr Mitochondrial function 
ProteomicsCooperative treatment effectiveness of VE821 and AUY922 in Ewing’s sarcoma cells
Ewing's sarcoma (ES) is the second most frequent bone cancer during childhood and adolescence originating from a translocation between the EWSR1 and the FLI1 gene, which inactivates BRCA-mediated DNA damage response. Both ATR and HSP90 inhibitors are promising new candidates in the field of ES treat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021562 | Pride
Ewing's sarcoma 
ProteomicsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffoldsMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds
Hematopoietic stem cell transplantation (HSCT) is successfully applied since the late 1950s, however, its efficacy still needs to be improved. A promising strategy is to transplant high numbers of pluripotent hematopoietic stem cells (HSCs). Therefore, an advanced ex vivo culture system is needed th...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD025849 | Pride
Hematopoietic stem cell transplantation (hsct) Proteomics Foxo Cholesterol Human hematopoietic stem cell (hsc) Srebp Biomimetic In vitro amplification 3d cell cultivation system Mtor Cell metabolism 
UnknownTwo interacting transcriptional coactivators cooperatively control plant immune responses.
Not available
S-EPMC8570602 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownVoluntary Deep Inspiration Breath-Hold (VDIBH) Whole-Breast Irradiation Assisted by Optical Surface Monitoring System (OSMS) in Patients With Left-Sided Breast Cancer: A Prospective Phase II Study.
Not available
S-EPMC10285586 | biostudies-literature
UnknownHuman urinary kallidinogenase in acute ischemic stroke: A single-arm, multicenter, phase IV study (RESK study).
Not available
S-EPMC8611767 | biostudies-literature
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