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ProteomicsInhalation of ACE2-expressing lung spheroid cell exosomes provides prophylactic protection against SARS-CoV-2
We demonstrated that lung spheroid cell derived exosomes (LSC-Exo) carry the parental cell’s ACE2 that are able to target lung, intercept SARS-CoV-2 entry, confer protection against SARS-CoV-2 infection. This LSC-Exo prophylaxis paradigm would not be limited by viral evolution, showing great potenti...
ORGANISM(S): Homo sapiens (Human) 
2024-01-13 | PXD047542 | Pride
Lc-ms Exosomes 
UnknownSingle-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Not available
S-EPMC9561780 | biostudies-literature
UnknownGenome-Wide Association Study Reveals Candidate Genes for Root-Related Traits in Rice.
Not available
S-EPMC9601093 | biostudies-literature
MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
ProteomicsFBL promotes cancer cell resistance to DNA damage by transcriptionally regulating BRCA1 via YBX1
In order to study the molecular mechanism of FBL in cells, this project constructed the full length of FBL into the SFB (S-Flag-SBP tag) vector, and constructed a stable cell line overexpressing FBL. Affinity chromatography combined with LC-MS/MS technology to screen FBL interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD034434 | Pride
Human Hct116 cells Nonolc-ms/ms Fbl 
ProteomicsJurkat 2D-LC-MS/MS - Enzyme Kinetics for Complex System Enables Accurate Determination of Specificity Constants of Numerous Substrates in a Mixture by Proteomics Platform
We found the ratio of substrate depletion is independent of other coexisted substrates under specific condition with the application of self-developed iteration approach. The further established simplified model was applied to determine the catalytic efficiencies of peptide substrates of a protease ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-08 | PXD004665 | Pride
Glu-c Catalytic efficiency Jurkat 
Proteomicsplasma-derived exosomes from healthy and osteosarcoma
Identification of proteins from plasma-derived exosomes of from healthy controls and osteosarcoma patients by LC-MS/MS in label-free quantification.
ORGANISM(S): Homo sapiens (Human) 
2021-07-02 | PXD024072 | Pride
Lc-ms/ms Exosomes Proteomics analysis 
ProteomicsTMT Proteomics in Z9 and E9 under Salt Stress
The impact of soil salinity on the growth, development, and yield of upland cotton. To elucidate the molecular mechanism of salt tolerance in upland cotton seedlings, proteomic methods were employed to study the proteomic characteristics of upland cotton leaves at the three-leaf stage after 12 hours...
ORGANISM(S): Gossypium Hirsutum 
2024-12-11 | PXD058796 |
ProteomicsPUMILIO Proteins in Colorectal Cancer: Tumor Growth Promoting Function and Potential as Therapeutic Targets
We employ Mass spectrum to investigate proteome of Pum1-Knockout, Pum2-Knockout and WT conditions in human colorectal cancer cell line Hct116. Overall design: In order to investigate whether Pum1 and Pum2 regulate their targets at their protein levels, we used Pum1-Knockout, Pum2-Knockout and WT Hct...
ORGANISM(S): Homo Sapiens 
2021-07-23 | PXD027513 |
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