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ProteomicsCoupled protein synthesis and ribosome-guided piRNA processing on mRNAs
PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. Previously, we showed that ribosomes guide the biogenesis of piRNAs from long non-coding RNAs (lncRNAs) after translating the short open reading frames (ORFs) near their 5′ cap. It remained unclear, how...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-17 | PXD027489 | Pride
Mouse Protein synthesis Pirna Mrna Testis Lc-ms/ms 
ProteomicsVCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
The mass spectrometry data were acquired using a Q Exactive HF mass spectrometer coupled with an UltiMate 3000 RSLCnano liquid chromatography system. Peptide samples were dissolved in a loading buffer, introduced via an autosampler, and separated on an analytical column (75 μm × 25 cm, C18, 1.9 μm, ...
ORGANISM(S): Homo Sapiens 
PXD055763 |
ProteomicsMmulatta - Liver, iBAQ with SILAC (Wangetal,amjphysiolendocrinolmetab2018)
abundance based on iBAQ with SILAC, Interaction consistency score: 20.0, Coverage: 35
ORGANISM(S): 9544 
2018-00-00 | 1498921887 | PAXDB
ProteomicsLabel-free quantitative proteomic analysis of rat liver tissue
In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free p...
ORGANISM(S): Rattus Rattus 
PXD015449 |
ProteomicsComparative Proteome Analysis of Four Sorghum Varieties Response to PEG Stress
Comparative Proteome Analysis of Four Sorghum Varieties Response to PEG Stress
ORGANISM(S): Sorghum Bicolor X Saccharum Hybrid Cultivar 
2022-05-12 | PXD033820 |
ProteomicsUbiquitome profiling reveals the landscape of ubiquitination regulation in young panicle
Ubiquitome profiling reveals the landscape of ubiquitination regulation in young panicle
ORGANISM(S): Oryza Sativa 
2017-12-11 | PXD023306 |
ProteomicsLabel-free Quantitative Proteomics Identifies Novel Plasma Biomarkers for Distinguishing Pulmonary Tuberculosis and Latent Infection
Lack of effective differential diagnostic methods between active tuberculosis (TB) and latent infection (LTBI) is still an obstacle for TB control. Furthermore, the molecular mechanism behind the progression from LTBI to active TB has been not elucidated until now. Therefore, we performed label-free...
ORGANISM(S): Homo Sapiens 
PXD056149 |
ProteomicsUSP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
Knock down the expression level of USP3 in osteosarcoma cell 143B and observe the proteins with altered ubiquitination levels.
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049717 |
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
ProteomicsComputational Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage and Applications to 15 Tumors
a computational strategy for the size optimization of DIA spectral library, which refines a comprehensive library by a prior analysis of DIA data of a particular tissue type
ORGANISM(S): Homo Sapiens 
2021-12-27 | PXD030648 |
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