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ProteomicsCoupled protein synthesis and ribosome-guided piRNA processing on mRNAs
PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for fertility. Previously, we showed that ribosomes guide the biogenesis of piRNAs from long non-coding RNAs (lncRNAs) after translating the short open reading frames (ORFs) near their 5′ cap. It remained unclear, how...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-17 | PXD027489 | Pride
Mouse Protein synthesis Pirna Mrna Testis Lc-ms/ms 
ProteomicsVCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
The mass spectrometry data were acquired using a Q Exactive HF mass spectrometer coupled with an UltiMate 3000 RSLCnano liquid chromatography system. Peptide samples were dissolved in a loading buffer, introduced via an autosampler, and separated on an analytical column (75 μm × 25 cm, C18, 1.9 μm, ...
ORGANISM(S): Homo Sapiens 
2024-09-10 | PXD055763 |
ProteomicsMmulatta - Liver, iBAQ with SILAC (Wangetal,amjphysiolendocrinolmetab2018)
abundance based on iBAQ with SILAC, Interaction consistency score: 20.0, Coverage: 35
ORGANISM(S): 9544 
2018-00-00 | 1498921887 | PAXDB
ProteomicsLabel-free quantitative proteomic analysis of rat liver tissue
In this study, the spleen deficiency syndrome rat model was built with reserpine injection method. At first, the intervention effect of SJZD on spleen deficiency syndrome was preliminary evaluation through pharmacodynamics study. By comparing the differences proteins of liver tissues by label-free p...
ORGANISM(S): Rattus Rattus 
2019-09-14 | PXD015449 |
ProteomicsComparative Proteome Analysis of Four Sorghum Varieties Response to PEG Stress
Comparative Proteome Analysis of Four Sorghum Varieties Response to PEG Stress
ORGANISM(S): Sorghum Bicolor X Saccharum Hybrid Cultivar 
2022-05-12 | PXD033820 |
ProteomicsUSP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
Knock down the expression level of USP3 in osteosarcoma cell 143B and observe the proteins with altered ubiquitination levels.
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049717 |
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
ProteomicsDPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins
we generated DPHL v2 from 1608 DDA-MS data acquired using Orbitrap mass spectrometers. The data included 586 DDA-MS newly acquired from 17 tissue types, while 1022 files were derived from DPHL v1. DPHL v2 thus comprises data from 24 sample types, including several cancer types . We generated four va...
ORGANISM(S): Homo Sapiens 
2023-01-18 | PXD039313 |
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